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• W2000040414 abstract "Oxygen is crucial to aerobic metabolism, but excesses of oxygen or reactive oxygen species (ROS) can injure cells. This minireview addresses two transcription factors that regulate several cellular responses to oxygen tension. Hypoxia inducible factor-1 (HIF-1) is a heterodimeric protein activated by hypoxia. Levels of HIF-1 are regulated by removal of the HIF-1alpha subunit through ubiquination and proteasomal destruction under normoxic conditions. Hypoxia inhibits the ubiquination of HIF-1alpha, preventing its destruction and allowing it to bind to hypoxia-responsive elements in gene promoter, enhancer, and intronic sequences. HIF-1 induces the expression of the hypoxia responsive genes vascular endothelial growth factor and erythropoietin. Its dysregulation has been implicated in von Hippel-Lindau disease. Nuclear factor kappaB (NFkappaB) is a family of pleotropic, dimeric transcription factors, and has a complex pattern of regulation. Under normoxic conditions, NFkappaB is bound to one of several inhibitory proteins (e.g., IkappaB) that prevent its nuclear translocation. Hyperoxia or elevations of ROS cause the ubiquination and destruction of the inhibitory proteins, freeing NFkappaB and allowing it to bind to target gene promoters. Hyperoxia in cell and animal models and acute lung injury in humans induce the expression of multiple proinflammatory cytokines through NFkappaB-dependent mechanisms. Although HIF-1 and NFkappaB respond to changes in pO(2), the precise nature of the oxygen sensing and transduction pathways is unclear in both cases. Both heme-protein and redox-sensitive mechanisms have been proposed. Improved understanding of oxygen-sensitive gene regulation may suggest targeted therapies for human disease." @default.
• W2000040414 created "2016-06-24" @default.
• W2000040414 creator A5068833247 @default.
• W2000040414 creator A5089732429 @default.
• W2000040414 date "2000-09-01" @default.
• W2000040414 modified "2023-10-14" @default.
• W2000040414 title "Oxygen Regulation of Gene Expression: A Study in Opposites" @default.
• W2000040414 cites W1488835155 @default.
• W2000040414 cites W1532516694 @default.
• W2000040414 cites W1545825939 @default.
• W2000040414 cites W1568529372 @default.
• W2000040414 cites W1579092429 @default.
• W2000040414 cites W1590514634 @default.
• W2000040414 cites W1749022239 @default.
• W2000040414 cites W1863824423 @default.
• W2000040414 cites W1869499975 @default.
• W2000040414 cites W1891283175 @default.
• W2000040414 cites W1968870654 @default.
• W2000040414 cites W1975426605 @default.
• W2000040414 cites W1976411950 @default.
• W2000040414 cites W1985831147 @default.
• W2000040414 cites W1991843895 @default.
• W2000040414 cites W1993608966 @default.
• W2000040414 cites W1997031088 @default.
• W2000040414 cites W1997447190 @default.
• W2000040414 cites W1997804749 @default.
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• W2000040414 cites W2010394923 @default.
• W2000040414 cites W2016839495 @default.
• W2000040414 cites W2022773473 @default.
• W2000040414 cites W2024206845 @default.
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• W2000040414 cites W2033800625 @default.
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• W2000040414 cites W2055426473 @default.
• W2000040414 cites W2057737390 @default.
• W2000040414 cites W2059129711 @default.
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• W2000040414 cites W2084471046 @default.
• W2000040414 cites W2087841059 @default.
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• W2000040414 doi "https://doi.org/10.1006/mgme.2000.3074" @default.
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