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- W2000046054 abstract "Abstract Twenty-one diazepam- and chlordimeform (CDM)-related compounds were synthesized by mimicking some parts of the 1,4-benzodiazepine tranquilizing drugs, and were tested for their insecticidal activity against the German cockroach. Some of these compounds showed knockdown effects and some were insecticidal. Against the German cockroach the most toxic CDM analog was N -propargyl CDM (compound 6), and that with a potent knockdown potency was compound 13 which has a structural resemblance to diazepam. Ligand-receptor binding assay was carried out, using [ 3 H]diazepam as a ligand to examine the relation between CDM-related compounds and the 1,4-benzodiazepines. The [ 3 H]diazepam binding to a specific site in the American cockroach brain was inhibited by the insecticidal compounds. Among these compounds a correlation exists between their inhibitory potency on specific [ 3 H]diazepam binding and their insecticidal activity, suggesting a possible significance of such an interaction with the diazepam binding site for the toxicity of these compounds against cockroaches." @default.
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- W2000046054 date "1986-12-01" @default.
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- W2000046054 title "Effects of diazepam and chlordimeform analogs on the German and the American cockroaches" @default.
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- W2000046054 doi "https://doi.org/10.1016/0048-3575(86)90067-2" @default.
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