Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000052617> ?p ?o ?g. }
- W2000052617 endingPage "85" @default.
- W2000052617 startingPage "85" @default.
- W2000052617 abstract "Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement and fatal systemic infection. Resistance to infection is associated with a T-helper-1 immune response that activates macrophages to kill the intracellular parasite in a nitric oxide-dependent manner. Conversely, disease progression is generally associated with a T-helper-2 response that activates humoral immunity. Current control is based on chemothera-peutic treatments which are expensive, toxic and associated with high relapse and resistance rates. Vaccination remains the best hope for control of all forms of the disease, and the development of a safe, effective and afford-able antileishmanial vaccine is a critical global public-health priority. Extensive evidence from studies in animal models indicates that solid protection can be achieved by immunization with defined subunit vaccines or live-at-tenuated strains of Leishmania. However, to date, no vaccine is available despite substantial efforts by many labo-ratories. Major impediments in Leishmania vaccine development include: lack of adequate funding from national and international agencies, problems related to the translation of data from animal models to human disease, and the transition from the laboratory to the field. Furthermore, a thorough understanding of protective immune re-sponses and generation and maintenance of the immunological memory, an important but least-studied aspect of antiparasitic vaccine development, during Leishmania infection is needed. This review focuses on the progress of the search for an effective vaccine against human and canine leishmaniasis." @default.
- W2000052617 created "2016-06-24" @default.
- W2000052617 creator A5010198660 @default.
- W2000052617 creator A5021654858 @default.
- W2000052617 creator A5029800696 @default.
- W2000052617 creator A5045571224 @default.
- W2000052617 creator A5062795375 @default.
- W2000052617 creator A5068348318 @default.
- W2000052617 date "2013-01-01" @default.
- W2000052617 modified "2023-10-16" @default.
- W2000052617 title "Development of Leishmania vaccines: predicting the future from past and present experience" @default.
- W2000052617 cites W1223371859 @default.
- W2000052617 cites W13635433 @default.
- W2000052617 cites W13689119 @default.
- W2000052617 cites W1481358372 @default.
- W2000052617 cites W1490261874 @default.
- W2000052617 cites W1533703122 @default.
- W2000052617 cites W1561717046 @default.
- W2000052617 cites W1581035845 @default.
- W2000052617 cites W1586815054 @default.
- W2000052617 cites W1630773707 @default.
- W2000052617 cites W1742639464 @default.
- W2000052617 cites W1861880998 @default.
- W2000052617 cites W1874018940 @default.
- W2000052617 cites W1963542761 @default.
- W2000052617 cites W1964200211 @default.
- W2000052617 cites W1966362727 @default.
- W2000052617 cites W1968109373 @default.
- W2000052617 cites W1969440030 @default.
- W2000052617 cites W1971413150 @default.
- W2000052617 cites W1973700190 @default.
- W2000052617 cites W1973830694 @default.
- W2000052617 cites W1984665950 @default.
- W2000052617 cites W1985190174 @default.
- W2000052617 cites W1985744831 @default.
- W2000052617 cites W1987829625 @default.
- W2000052617 cites W1988721092 @default.
- W2000052617 cites W1989782699 @default.
- W2000052617 cites W1994634337 @default.
- W2000052617 cites W1995725063 @default.
- W2000052617 cites W1998367326 @default.
- W2000052617 cites W2000200374 @default.
- W2000052617 cites W2004912026 @default.
- W2000052617 cites W2005250441 @default.
- W2000052617 cites W2008959284 @default.
- W2000052617 cites W2009237591 @default.
- W2000052617 cites W2010105574 @default.
- W2000052617 cites W2010155234 @default.
- W2000052617 cites W2012862509 @default.
- W2000052617 cites W2014458110 @default.
- W2000052617 cites W2015405091 @default.
- W2000052617 cites W2016442110 @default.
- W2000052617 cites W2017583352 @default.
- W2000052617 cites W2017725241 @default.
- W2000052617 cites W2019255983 @default.
- W2000052617 cites W2021712302 @default.
- W2000052617 cites W2022412760 @default.
- W2000052617 cites W2023088528 @default.
- W2000052617 cites W2027028977 @default.
- W2000052617 cites W2029024740 @default.
- W2000052617 cites W2032056858 @default.
- W2000052617 cites W2033785669 @default.
- W2000052617 cites W2035019807 @default.
- W2000052617 cites W2041703347 @default.
- W2000052617 cites W2050886892 @default.
- W2000052617 cites W2051703773 @default.
- W2000052617 cites W2053150635 @default.
- W2000052617 cites W2053293487 @default.
- W2000052617 cites W2053895943 @default.
- W2000052617 cites W2054233019 @default.
- W2000052617 cites W2058136774 @default.
- W2000052617 cites W2058656891 @default.
- W2000052617 cites W2059318013 @default.
- W2000052617 cites W2060098125 @default.
- W2000052617 cites W2060134893 @default.
- W2000052617 cites W2063591562 @default.
- W2000052617 cites W2064642543 @default.
- W2000052617 cites W2065106221 @default.
- W2000052617 cites W2067801913 @default.
- W2000052617 cites W2072263732 @default.
- W2000052617 cites W2074216759 @default.
- W2000052617 cites W2075365494 @default.
- W2000052617 cites W2077554902 @default.
- W2000052617 cites W2083670895 @default.
- W2000052617 cites W2084568316 @default.
- W2000052617 cites W2085285405 @default.
- W2000052617 cites W2086879443 @default.
- W2000052617 cites W2086967479 @default.
- W2000052617 cites W2088256755 @default.
- W2000052617 cites W2092135249 @default.
- W2000052617 cites W2092390270 @default.
- W2000052617 cites W2094945005 @default.
- W2000052617 cites W2095345300 @default.
- W2000052617 cites W2095999453 @default.
- W2000052617 cites W2099284132 @default.
- W2000052617 cites W2099340618 @default.
- W2000052617 cites W2099636172 @default.
- W2000052617 cites W2105137500 @default.