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- W2000063219 abstract "Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5‐HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes ( P < 0.02, odds ratio 2.18, 95% CI 1.10–4.20). Conclusion: The ‘ss’ or ‘sl’ genotype at the 5‐HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness." @default.
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- W2000063219 date "2009-01-11" @default.
- W2000063219 modified "2023-10-17" @default.
- W2000063219 title "The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders" @default.
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- W2000063219 doi "https://doi.org/10.1111/j.1600-0447.2008.01273.x" @default.
- W2000063219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3940489" @default.
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