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• W2000066959 endingPage "1957" @default.
• W2000066959 startingPage "1946" @default.
• W2000066959 abstract "Myostatin, a member of the TGF superfamily, is sufficient to induce skeletal muscle atrophy. Myostatin-induced atrophy is associated with increases in E3-ligase atrogin-1 expression and protein degradation and decreases in Akt/mechanistic target of rapamycin (mTOR) signaling and protein synthesis. Myostatin signaling activates the transcription factor Smad3 (Small Mothers Against Decapentaplegic), which has been shown to be necessary for myostatin-induced atrogin-1 expression and atrophy; however, it is not known whether Smad3 is sufficient to induce these events or whether Smad3 simply plays a permissive role. Thus, the aim of this study was to address these questions with an in vivo model. To accomplish this goal, in vivo transfection of plasmid DNA was used to create transient transgenic mouse skeletal muscles, and our results show for the first time that Smad3 expression is sufficient to stimulate atrogin-1 promoter activity, inhibit Akt/mTOR signaling and protein synthesis, and induce muscle fiber atrophy. Moreover, we propose that Akt/mTOR signaling is inhibited by a Smad3-induced decrease in microRNA-29 (miR-29) expression and a subsequent increase in the translation of phosphatase and tensin homolog (PTEN) mRNA. Smad3 is also sufficient to inhibit peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) promoter activity and to increase FoxO (Forkhead Box Protein, Subclass O)-mediated signaling and the promoter activity of plasminogen activator inhibitor 1 (PAI-1). Combined, this study provides the first evidence that Smad3 is sufficient to regulate many of the events associated with myostatin-induced atrophy and therefore suggests that Smad3 signaling may be a viable target for therapies aimed at preventing myostatin-induced muscle atrophy." @default.
• W2000066959 created "2016-06-24" @default.
• W2000066959 creator A5028632370 @default.
• W2000066959 creator A5051527512 @default.
• W2000066959 creator A5061361986 @default.
• W2000066959 creator A5069266537 @default.
• W2000066959 date "2013-11-01" @default.
• W2000066959 modified "2023-10-09" @default.
• W2000066959 title "Smad3 Induces Atrogin-1, Inhibits mTOR and Protein Synthesis, and Promotes Muscle Atrophy In Vivo" @default.
• W2000066959 cites W1930882462 @default.
• W2000066959 cites W1965705624 @default.
• W2000066959 cites W1966662292 @default.
• W2000066959 cites W1971189666 @default.
• W2000066959 cites W1971857747 @default.
• W2000066959 cites W1972023001 @default.
• W2000066959 cites W1972962054 @default.
• W2000066959 cites W1977548231 @default.
• W2000066959 cites W1977713833 @default.
• W2000066959 cites W1978832519 @default.
• W2000066959 cites W1981480973 @default.
• W2000066959 cites W1983415262 @default.
• W2000066959 cites W1990962636 @default.
• W2000066959 cites W1991002945 @default.
• W2000066959 cites W1992845452 @default.
• W2000066959 cites W1993476327 @default.
• W2000066959 cites W1995188901 @default.
• W2000066959 cites W1996657560 @default.
• W2000066959 cites W1997472202 @default.
• W2000066959 cites W2000310944 @default.
• W2000066959 cites W2003330837 @default.
• W2000066959 cites W2005366749 @default.
• W2000066959 cites W2006545231 @default.
• W2000066959 cites W2009227185 @default.
• W2000066959 cites W2009358874 @default.
• W2000066959 cites W2013140962 @default.
• W2000066959 cites W2029816532 @default.
• W2000066959 cites W2031469693 @default.
• W2000066959 cites W2032035791 @default.
• W2000066959 cites W2033797333 @default.
• W2000066959 cites W2033924360 @default.
• W2000066959 cites W2035555824 @default.
• W2000066959 cites W2046527364 @default.
• W2000066959 cites W2048424792 @default.
• W2000066959 cites W2048569338 @default.
• W2000066959 cites W2051437976 @default.
• W2000066959 cites W2055150513 @default.
• W2000066959 cites W2060031713 @default.
• W2000066959 cites W2061495510 @default.
• W2000066959 cites W2062390485 @default.
• W2000066959 cites W2064590658 @default.
• W2000066959 cites W2065284473 @default.
• W2000066959 cites W2065426370 @default.
• W2000066959 cites W2069055522 @default.
• W2000066959 cites W2072152524 @default.
• W2000066959 cites W2072363222 @default.
• W2000066959 cites W2073449316 @default.
• W2000066959 cites W2076755359 @default.
• W2000066959 cites W2079838847 @default.
• W2000066959 cites W2088689184 @default.
• W2000066959 cites W2093316681 @default.
• W2000066959 cites W2094346461 @default.
• W2000066959 cites W2100688137 @default.
• W2000066959 cites W2104063796 @default.
• W2000066959 cites W2106883683 @default.
• W2000066959 cites W2107696299 @default.
• W2000066959 cites W2109050641 @default.
• W2000066959 cites W2113836802 @default.
• W2000066959 cites W2116769367 @default.
• W2000066959 cites W2117741579 @default.
• W2000066959 cites W2124205424 @default.
• W2000066959 cites W2132813206 @default.
• W2000066959 cites W2133113184 @default.
• W2000066959 cites W2138904483 @default.
• W2000066959 cites W2140401368 @default.
• W2000066959 cites W2141543467 @default.
• W2000066959 cites W2147680529 @default.
• W2000066959 cites W2151258296 @default.
• W2000066959 cites W2153844934 @default.
• W2000066959 cites W2155290141 @default.
• W2000066959 cites W2155685150 @default.
• W2000066959 cites W2156204535 @default.
• W2000066959 cites W2156865358 @default.
• W2000066959 cites W2158254766 @default.
• W2000066959 cites W2164615751 @default.
• W2000066959 cites W2165761157 @default.
• W2000066959 cites W2167033587 @default.
• W2000066959 cites W2167512318 @default.
• W2000066959 cites W2170262804 @default.
• W2000066959 cites W293972337 @default.
• W2000066959 cites W2038030225 @default.
• W2000066959 doi "https://doi.org/10.1210/me.2013-1194" @default.
• W2000066959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3805852" @default.
• W2000066959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24002653" @default.
• W2000066959 hasPublicationYear "2013" @default.
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