Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000071569> ?p ?o ?g. }
- W2000071569 endingPage "335" @default.
- W2000071569 startingPage "325" @default.
- W2000071569 abstract "Porphyromonas gingivalis lipopolysaccharide (LPS) is a crucial virulence factor strongly involved in the development of chronic periodontitis. It displays a significant amount of lipid A structural heterogeneity, containing both tetra- (LPS(1435/1449) ) and penta-acylated (LPS( 1690)) lipid A structures with opposing effects on E-selectin expression in human endothelial cells. Little is known about how these two isoforms of P. gingivalis LPS could differentially affect host innate immune responses in human gingival epithelia. The present study compares the modulatory effects of P. gingivalis LPS(1435/1449) and LPS(1690) on the expression of human beta-defensins (hBDs) in the reconstituted human gingival epithelium, and examines the involvements of a panel of pattern recognition receptors in the modulatory effects concerned. It is shown that hBD-1, hBD-2 and hBD-3 mRNAs are significantly up-regulated by P. gingivalis LPS(1690), but down-regulated by P. gingivalis LPS( 1435/1449). Toll-like receptor (TLR) 2 and CD14 mRNAs are also differentially regulated, and the modulation of hBD-2 expression may be through the co-operation of both TLR2 and TLR4. This study suggests that P. gingivalis LPS with different lipid A structures could differentially modulate host innate immune responses in human gingival epithelia, which may be a hitherto undescribed novel pathogenic mechanism of P. gingivalis in periodontal pathogenesis." @default.
- W2000071569 created "2016-06-24" @default.
- W2000071569 creator A5009466623 @default.
- W2000071569 creator A5014120734 @default.
- W2000071569 creator A5017815821 @default.
- W2000071569 creator A5065218610 @default.
- W2000071569 creator A5066413125 @default.
- W2000071569 date "2009-08-12" @default.
- W2000071569 modified "2023-10-03" @default.
- W2000071569 title "Differential modulation of human β-defensins expression in human gingival epithelia by Porphyromonas gingivalis lipopolysaccharide with tetra- and penta-acylated lipid A structures" @default.
- W2000071569 cites W1504160997 @default.
- W2000071569 cites W1571292455 @default.
- W2000071569 cites W1732204574 @default.
- W2000071569 cites W1765362282 @default.
- W2000071569 cites W1837256871 @default.
- W2000071569 cites W1897355343 @default.
- W2000071569 cites W1898385642 @default.
- W2000071569 cites W1968631247 @default.
- W2000071569 cites W1969734205 @default.
- W2000071569 cites W1974508755 @default.
- W2000071569 cites W1979584246 @default.
- W2000071569 cites W1992579069 @default.
- W2000071569 cites W2013245073 @default.
- W2000071569 cites W2016862474 @default.
- W2000071569 cites W2025267297 @default.
- W2000071569 cites W2026269930 @default.
- W2000071569 cites W2027740390 @default.
- W2000071569 cites W2033622801 @default.
- W2000071569 cites W2048446313 @default.
- W2000071569 cites W2053344942 @default.
- W2000071569 cites W2057809738 @default.
- W2000071569 cites W2060428272 @default.
- W2000071569 cites W2080857291 @default.
- W2000071569 cites W2094036101 @default.
- W2000071569 cites W2094741750 @default.
- W2000071569 cites W2099362332 @default.
- W2000071569 cites W2104159258 @default.
- W2000071569 cites W2107715779 @default.
- W2000071569 cites W2109623522 @default.
- W2000071569 cites W2121198373 @default.
- W2000071569 cites W2125323026 @default.
- W2000071569 cites W2128315833 @default.
- W2000071569 cites W2137486650 @default.
- W2000071569 cites W2141515720 @default.
- W2000071569 cites W2151258906 @default.
- W2000071569 cites W2165935955 @default.
- W2000071569 cites W2170442599 @default.
- W2000071569 cites W2288913919 @default.
- W2000071569 doi "https://doi.org/10.1177/1753425909104899" @default.
- W2000071569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19675119" @default.
- W2000071569 hasPublicationYear "2009" @default.
- W2000071569 type Work @default.
- W2000071569 sameAs 2000071569 @default.
- W2000071569 citedByCount "44" @default.
- W2000071569 countsByYear W20000715692012 @default.
- W2000071569 countsByYear W20000715692013 @default.
- W2000071569 countsByYear W20000715692014 @default.
- W2000071569 countsByYear W20000715692015 @default.
- W2000071569 countsByYear W20000715692016 @default.
- W2000071569 countsByYear W20000715692017 @default.
- W2000071569 countsByYear W20000715692018 @default.
- W2000071569 countsByYear W20000715692019 @default.
- W2000071569 countsByYear W20000715692020 @default.
- W2000071569 countsByYear W20000715692021 @default.
- W2000071569 countsByYear W20000715692022 @default.
- W2000071569 countsByYear W20000715692023 @default.
- W2000071569 crossrefType "journal-article" @default.
- W2000071569 hasAuthorship W2000071569A5009466623 @default.
- W2000071569 hasAuthorship W2000071569A5014120734 @default.
- W2000071569 hasAuthorship W2000071569A5017815821 @default.
- W2000071569 hasAuthorship W2000071569A5065218610 @default.
- W2000071569 hasAuthorship W2000071569A5066413125 @default.
- W2000071569 hasConcept C126322002 @default.
- W2000071569 hasConcept C129437159 @default.
- W2000071569 hasConcept C136449434 @default.
- W2000071569 hasConcept C144464004 @default.
- W2000071569 hasConcept C185592680 @default.
- W2000071569 hasConcept C203014093 @default.
- W2000071569 hasConcept C2776070231 @default.
- W2000071569 hasConcept C2776709828 @default.
- W2000071569 hasConcept C2778513237 @default.
- W2000071569 hasConcept C2778754761 @default.
- W2000071569 hasConcept C2780183776 @default.
- W2000071569 hasConcept C2780385504 @default.
- W2000071569 hasConcept C2781236682 @default.
- W2000071569 hasConcept C71924100 @default.
- W2000071569 hasConcept C86803240 @default.
- W2000071569 hasConcept C8891405 @default.
- W2000071569 hasConcept C89423630 @default.
- W2000071569 hasConcept C95444343 @default.
- W2000071569 hasConceptScore W2000071569C126322002 @default.
- W2000071569 hasConceptScore W2000071569C129437159 @default.
- W2000071569 hasConceptScore W2000071569C136449434 @default.
- W2000071569 hasConceptScore W2000071569C144464004 @default.
- W2000071569 hasConceptScore W2000071569C185592680 @default.
- W2000071569 hasConceptScore W2000071569C203014093 @default.
- W2000071569 hasConceptScore W2000071569C2776070231 @default.
- W2000071569 hasConceptScore W2000071569C2776709828 @default.