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- W2000084927 endingPage "2024" @default.
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- W2000084927 abstract "We report an improved synthetic strategy for the preparation of the amyloidogenic protein fragment β-amyloid(1–43). The scheme is based upon the generation of highly soluble N-(2-hydroxy-4-methoxybenzyl)(Hmb) backbone amide-protected intermediates. Optimal positioning of backbone protection at glycines25,29,33,37 together with phenylalanine20, was determined from a β-hairpin model derived for the C-terminal region of the resin-bound peptide. This improved scheme provides the final product in 28% overall yield." @default.
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- W2000084927 title "Improved preparation of β-amyloid(1–43): structural insight leading to optimised positioning of N-(2-hydroxy-4-methoxybenzyl)(Hmb) backbone amide protection" @default.
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- W2000084927 doi "https://doi.org/10.1039/p19950002019" @default.
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