FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000093612> ?p ?o ?g. }

• W2000093612 endingPage "83" @default.
• W2000093612 startingPage "75" @default.
• W2000093612 abstract "The purpose of this study was to investigate the toxicity of a series of poly(lactide-co-glycolic) (PLGA) nanoparticles on human-like THP-1 macrophages. Positively-, negatively-charged and neutral nanoparticles (200 nm) were prepared using chitosan (CS), poloxamer 188 (PF68) and poly(vinyl alcohol) (PVA) as stabilizer. Stabilizer-free PLGA nanoparticles were obtained as well. When used at therapeutically relevant concentrations (up to 0.1 mg/mL in vitro), all tested nanoparticles showed no or scarce signs of toxicity, as assessed by cell mitochondrial activity, induction of apoptosis and necrosis, production of intracellular reactive oxygen species (ROS) and secretion of pro-inflammatory cytokines. At high concentrations (above 1mg/mL), cytotoxicity was found to be induced by the presence of stabilizers, whatever the toxicological pattern of the stabilizer itself. While stabilizer-free PLGA nanoparticles exerted no cytotoxicity, the slightly cytotoxic CS polymer conferred PLGA nanoparticles significant cytotoxicity when used as nanoparticle stabilizer; more surprisingly, the otherwise innocuous PVA and PF68 polymers also conferred a significant cytotoxicity to PLGA nanoparticles. These results unveiled the critical toxicological contribution played by stabilizers used for the formulation of PLGA nanoparticles when used at high concentrations, which may have implications for local toxicities of PLGA-based nanomedicine, and provided additional insight in cytotoxic effects of internalized nanoparticles." @default.
• W2000093612 created "2016-06-24" @default.
• W2000093612 creator A5017558433 @default.
• W2000093612 creator A5045188549 @default.
• W2000093612 creator A5046179749 @default.
• W2000093612 creator A5052198645 @default.
• W2000093612 creator A5056949894 @default.
• W2000093612 creator A5058791776 @default.
• W2000093612 creator A5073174129 @default.
• W2000093612 date "2015-03-01" @default.
• W2000093612 modified "2023-10-18" @default.
• W2000093612 title "Surface coating mediates the toxicity of polymeric nanoparticles towards human-like macrophages" @default.
• W2000093612 cites W1926532709 @default.
• W2000093612 cites W1972348350 @default.
• W2000093612 cites W1978726442 @default.
• W2000093612 cites W1988554374 @default.
• W2000093612 cites W2003474213 @default.
• W2000093612 cites W2009974403 @default.
• W2000093612 cites W2017350973 @default.
• W2000093612 cites W2020398834 @default.
• W2000093612 cites W2025418692 @default.
• W2000093612 cites W2031904037 @default.
• W2000093612 cites W2061025835 @default.
• W2000093612 cites W2062342035 @default.
• W2000093612 cites W2070032426 @default.
• W2000093612 cites W2082458560 @default.
• W2000093612 cites W2094388348 @default.
• W2000093612 cites W2127310510 @default.
• W2000093612 cites W2145333524 @default.
• W2000093612 cites W2169689625 @default.
• W2000093612 cites W4231049616 @default.
• W2000093612 doi "https://doi.org/10.1016/j.ijpharm.2014.11.042" @default.
• W2000093612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25448553" @default.
• W2000093612 hasPublicationYear "2015" @default.
• W2000093612 type Work @default.
• W2000093612 sameAs 2000093612 @default.
• W2000093612 citedByCount "101" @default.
• W2000093612 countsByYear W20000936122015 @default.
• W2000093612 countsByYear W20000936122016 @default.
• W2000093612 countsByYear W20000936122017 @default.
• W2000093612 countsByYear W20000936122018 @default.
• W2000093612 countsByYear W20000936122019 @default.
• W2000093612 countsByYear W20000936122020 @default.
• W2000093612 countsByYear W20000936122021 @default.
• W2000093612 countsByYear W20000936122022 @default.
• W2000093612 countsByYear W20000936122023 @default.
• W2000093612 crossrefType "journal-article" @default.
• W2000093612 hasAuthorship W2000093612A5017558433 @default.
• W2000093612 hasAuthorship W2000093612A5045188549 @default.
• W2000093612 hasAuthorship W2000093612A5046179749 @default.
• W2000093612 hasAuthorship W2000093612A5052198645 @default.
• W2000093612 hasAuthorship W2000093612A5056949894 @default.
• W2000093612 hasAuthorship W2000093612A5058791776 @default.
• W2000093612 hasAuthorship W2000093612A5073174129 @default.
• W2000093612 hasConcept C101335993 @default.
• W2000093612 hasConcept C109316439 @default.
• W2000093612 hasConcept C12554922 @default.
• W2000093612 hasConcept C127413603 @default.
• W2000093612 hasConcept C127445965 @default.
• W2000093612 hasConcept C15083742 @default.
• W2000093612 hasConcept C155672457 @default.
• W2000093612 hasConcept C15920480 @default.
• W2000093612 hasConcept C171250308 @default.
• W2000093612 hasConcept C178790620 @default.
• W2000093612 hasConcept C185592680 @default.
• W2000093612 hasConcept C192562407 @default.
• W2000093612 hasConcept C202751555 @default.
• W2000093612 hasConcept C2777502316 @default.
• W2000093612 hasConcept C2779732960 @default.
• W2000093612 hasConcept C2780165375 @default.
• W2000093612 hasConcept C29730261 @default.
• W2000093612 hasConcept C48349386 @default.
• W2000093612 hasConcept C521977710 @default.
• W2000093612 hasConcept C55493867 @default.
• W2000093612 hasConcept C78519656 @default.
• W2000093612 hasConcept C86803240 @default.
• W2000093612 hasConceptScore W2000093612C101335993 @default.
• W2000093612 hasConceptScore W2000093612C109316439 @default.
• W2000093612 hasConceptScore W2000093612C12554922 @default.
• W2000093612 hasConceptScore W2000093612C127413603 @default.
• W2000093612 hasConceptScore W2000093612C127445965 @default.
• W2000093612 hasConceptScore W2000093612C15083742 @default.
• W2000093612 hasConceptScore W2000093612C155672457 @default.
• W2000093612 hasConceptScore W2000093612C15920480 @default.
• W2000093612 hasConceptScore W2000093612C171250308 @default.
• W2000093612 hasConceptScore W2000093612C178790620 @default.
• W2000093612 hasConceptScore W2000093612C185592680 @default.
• W2000093612 hasConceptScore W2000093612C192562407 @default.
• W2000093612 hasConceptScore W2000093612C202751555 @default.
• W2000093612 hasConceptScore W2000093612C2777502316 @default.
• W2000093612 hasConceptScore W2000093612C2779732960 @default.
• W2000093612 hasConceptScore W2000093612C2780165375 @default.
• W2000093612 hasConceptScore W2000093612C29730261 @default.
• W2000093612 hasConceptScore W2000093612C48349386 @default.
• W2000093612 hasConceptScore W2000093612C521977710 @default.
• W2000093612 hasConceptScore W2000093612C55493867 @default.
• W2000093612 hasConceptScore W2000093612C78519656 @default.
• W2000093612 hasConceptScore W2000093612C86803240 @default.

• next