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• W2000094462 startingPage "542" @default.
• W2000094462 abstract "Rats were trained to respond with intravenous cocaine as the reinforcer under a fixed interval 15-min schedule, during which conditioned stimuli paired with cocaine were presented contingent on completion of a fixed ratio of 10 responses (i.e., second-order schedule of reinforcement). The effects of contingent and noncontingent cocaine were investigated. The results show that pretreatment with noncontingent (i.e., experimenter-administered) cocaine led to a satiation-like effect that was reflected in decreased numbers of responses and a tendency for an increased latency to initiate responding when the doses of cocaine administered were similar to or higher than the training/maintenance dose of cocaine. By contrast, noncontingent administration of cocaine doses lower than the training/maintenance dose, and response-contingent cocaine administration, led to increased drug-seeking behavior, as reflected in increased numbers of responses. The present data indicate that at least two factors determine whether administration of cocaine would lead to drug-seeking behavior: whether the cocaine administration is contingent or noncontingent, and the relative magnitude of the cocaine dose administered in relation to the training/maintenance dose of cocaine." @default.
• W2000094462 created "2016-06-24" @default.
• W2000094462 creator A5060932935 @default.
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• W2000094462 creator A5078339333 @default.
• W2000094462 date "1999-06-01" @default.
• W2000094462 modified "2023-09-23" @default.
• W2000094462 title "Effects of Contingent and Non-Contingent Cocaine on Drug-Seeking Behavior Measured Using a Second-Order Schedule of Cocaine Reinforcement in Rats" @default.
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• W2000094462 doi "https://doi.org/10.1016/s0893-133x(98)00080-3" @default.
• W2000094462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10327424" @default.
• W2000094462 hasPublicationYear "1999" @default.
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