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- W2000096543 abstract "We have previously produced transgenic G-InsKi mice, a model allowing regulated portal insulin delivery from gastric G cells without using beta cells. Here, we report that in G-InsKi mice portal levels of transgenic human insulin are 6-fold higher than in peripheral circulation. Peptone-induced release of transgenic human insulin from G cells preferentially stimulated signaling cascades in the liver rather than in peripheral insulin-sensitive tissues, as judged by tyrosine phosphorylation of insulin receptor beta subunit and phosphorylation of protein kinase Akt/PKB at Thr-308. G-InsKi mice provide a novel animal model for elucidating direct effects of insulin on liver functions." @default.
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- W2000096543 date "2007-03-01" @default.
- W2000096543 modified "2023-10-18" @default.
- W2000096543 title "Transgenic insulin released from G cells preferentially signals in the liver" @default.
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- W2000096543 doi "https://doi.org/10.1016/j.bbrc.2007.01.059" @default.
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