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- W2000097926 abstract "Studies on the kinetics of unscheduled DNA synthesis in human lymphocytes following high radiation doses (Radiation Res., 1969, 39, pp. 400–412) have been extended to the dose range of 600–2400 rad. As in the case of the high doses, the data can be modeled in terms of a single enzyme system. There are, however, differences; at high doses the ratio of radiation-induced substrate (lesions) to enzyme is much greater than 1 and a Michaelis Menten plot of the data is possible. Below 1000 rad, this ratio appears to be less than 1 and consequently the Michaelis Menten plot breaks down. In the dose range of 600–2400 rad, the data are represented in terms of a dose-dependent rate constant. The rate constant increases as the dose decreases from 2400 to about 1000 rad and then reaches a constant value of 3 h−1 which corresponds to a half-life of about 14 min. Under the assumption of a single enzyme system, the high-dose data and low-dose data can be used together to obtain an estimate of the average number of enzymes per lymphocyte. A value of 10–20 thousand enzyme units per cell is obtained. This is equivalent to 1 enzyme unit per 2 to 4·108 dalton of DNA. At low doses, the amount of exogenous thymidine (TdR) incorporated as a result of radiation-induced unscheduled DNA synthesis amounts to 6 molecules of TdR/rad/cell at saturated concentration of exogenous TdR (about 5μM). Coupled with the enzyme model, this amounts to approximately 10–20 lesions per rad or that 1 or 2 nucleotides are incorporated per lesion." @default.
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- W2000097926 title "Unscheduled DNA synthesis at low X-ray doses" @default.
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- W2000097926 doi "https://doi.org/10.1016/0027-5107(70)90050-3" @default.
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