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- W2000097985 abstract "The kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in most vertebrates. However, this presumption has not been tested vigorously in nonmammalian vertebrates. Distinct from mammals, multiple kiss1/gpr54 paralogous genes (kiss/kissr) have been identified in nonmammalian vertebrates, raising the possibility of functional redundancy among these genes. In this study, we have systematically generated the zebrafish kiss1−/−, kiss2−/−, and kiss1−/−;kiss2−/− mutant lines as well as the kissr1−/−, kissr2−/−, and kissr1−/−;kissr2−/− mutant lines using transcription activator-like effector nucleases. We have demonstrated that spermatogenesis and folliculogenesis as well as reproductive capability are not impaired in all of these 6 mutant lines. Collectively, our results indicate that kiss/kissr signaling is not absolutely required for zebrafish reproduction, suggesting that the kiss/kissr systems play nonessential roles for reproduction in certain nonmammalian vertebrates. These findings also demonstrated that fish and mammals have evolved different strategies for neuroendocrine control of reproduction." @default.
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- W2000097985 date "2014-11-18" @default.
- W2000097985 modified "2023-10-15" @default.
- W2000097985 title "The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies" @default.
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- W2000097985 doi "https://doi.org/10.1210/en.2014-1204" @default.
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