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- W2000102903 abstract "Aim : To analyse p53 immunoreactivity in 207 biopsy specimens of lichen sclerosus (LS) and ‘differentiated vulvar intraepithelial neoplasia’ (d‐VIN), a postulated precursor lesion for LS‐associated vulvar squamous cell carcinoma (SCC), which is characterized by atypical basal keratinocyte proliferations with p53+ basal/suprabasal keratinocyte nuclei. Methods and results : Forty early, 78 classic, 30 hypertrophic vulvar LS, 26 paediatric vulvar and penile LS, 33 vulvar LS‐associated SCC and 30 vulvar/penile control specimens were examined for p53 expression and the presence of d‐VIN. Nuclear p53 staining was observed in 175/207 LS biopsy specimems. Eighty percent of early and 69% of paediatric LS showed discontinuous/continous p53 staining in basal keratinocytes. Classic LS showed no p53 staining in 17%, discontinuous basal keratinocyte staining in 20%, continuous basal keratinocyte staining in 58%, basal/suprabasal staining in 5%. Hypertrophic LS revealed basal keratinocyte staining in 32% and basal/suprabasal staining in 61%. p53 staining was associated with sclerosis of blood vessels and dermis, lymphoid infiltrates, vasculitis and hypertrophic LS. d‐VIN was seen in 2% of LS alone and in 24% of LS‐associated SCC. Conclusion : d‐VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS." @default.
- W2000102903 created "2016-06-24" @default.
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- W2000102903 date "2006-01-19" @default.
- W2000102903 modified "2023-10-18" @default.
- W2000102903 title "p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN)" @default.
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- W2000102903 doi "https://doi.org/10.1111/j.1365-2559.2005.02321.x" @default.
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