FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000106816> ?p ?o ?g. }

• W2000106816 endingPage "1191" @default.
• W2000106816 startingPage "1182" @default.
• W2000106816 abstract "Objective: We investigated subcutaneous adipose tissue expression of FOXC2 and selected genes involved in brown adipogenesis in adult human subjects in whom we have previously identified a reduced potential of precursor cell commitment to adipose-lineage differentiation in relation to insulin resistance. Research Methods and Procedure: Gene expression was studied using quantitative real time polymerase chain reaction. The relation between the expression of brown adipogenic genes and the genes involved in progenitor cell commitment, adipose cell size, and insulin sensitivity in vivo was analyzed. Results: The expression of FOXC2, MASK, MAP3K5, retinoblastoma protein (pRb), peroxisome proliferator-activated protein gamma (PPARγ), and retinoid X receptor gamma (RXRγ) was decreased in the insulin-resistant compared with insulin-sensitive subjects, whereas PPARγ-2 and CCAAT/enhancer binding protein alpha (C/EBPα) showed no differential expression. The FOXC2 expression correlated with that of Notch and Wnt signaling genes, as well as of the genes studied participating in brown adipogenesis, including MASK, MAP3K5, PPARγ, pRb, RXRγ, and PGC-1. A second-level correlation between PPARγ and UCP-1 was also significant. In addition, the expression of MASK, MAP3K5, pRb, RXRγ, and PGC-1 inversely correlated with adipose cell mass and also correlated with the glucose disposal rate in vivo. Discussion: Our results suggest that a reduced brown adipose phenotype is associated with insulin resistance and that a basal brown adipose phenotype may be important for maintaining normal insulin sensitivity." @default.
• W2000106816 created "2016-06-24" @default.
• W2000106816 creator A5002161503 @default.
• W2000106816 creator A5009603891 @default.
• W2000106816 creator A5028599620 @default.
• W2000106816 date "2003-10-01" @default.
• W2000106816 modified "2023-09-25" @default.
• W2000106816 title "Reduced Expression of FOXC2 and Brown Adipogenic Genes in Human Subjects with Insulin Resistance" @default.
• W2000106816 cites W103142017 @default.
• W2000106816 cites W1524321743 @default.
• W2000106816 cites W1580569338 @default.
• W2000106816 cites W1587875569 @default.
• W2000106816 cites W1675830194 @default.
• W2000106816 cites W1839100929 @default.
• W2000106816 cites W1886154307 @default.
• W2000106816 cites W1900866157 @default.
• W2000106816 cites W1963496112 @default.
• W2000106816 cites W1970328728 @default.
• W2000106816 cites W1972836378 @default.
• W2000106816 cites W1975853332 @default.
• W2000106816 cites W1983514972 @default.
• W2000106816 cites W1996405087 @default.
• W2000106816 cites W2006433855 @default.
• W2000106816 cites W2011237068 @default.
• W2000106816 cites W2017153527 @default.
• W2000106816 cites W2018111782 @default.
• W2000106816 cites W2020688809 @default.
• W2000106816 cites W2027948418 @default.
• W2000106816 cites W2034580062 @default.
• W2000106816 cites W2042706232 @default.
• W2000106816 cites W2053786812 @default.
• W2000106816 cites W2060333964 @default.
• W2000106816 cites W2060846519 @default.
• W2000106816 cites W2066651821 @default.
• W2000106816 cites W2072919666 @default.
• W2000106816 cites W2092761737 @default.
• W2000106816 cites W2097899015 @default.
• W2000106816 cites W2098464902 @default.
• W2000106816 cites W2107551430 @default.
• W2000106816 cites W2109963685 @default.
• W2000106816 cites W2110692758 @default.
• W2000106816 cites W2111122566 @default.
• W2000106816 cites W2117821842 @default.
• W2000106816 cites W2118623169 @default.
• W2000106816 cites W2129138669 @default.
• W2000106816 cites W2132643262 @default.
• W2000106816 cites W2134920653 @default.
• W2000106816 cites W2136040666 @default.
• W2000106816 cites W2139437192 @default.
• W2000106816 cites W2145097782 @default.
• W2000106816 cites W2154797259 @default.
• W2000106816 cites W2154861644 @default.
• W2000106816 cites W2162262531 @default.
• W2000106816 cites W2164108959 @default.
• W2000106816 cites W2167096785 @default.
• W2000106816 cites W2319291662 @default.
• W2000106816 cites W2337786074 @default.
• W2000106816 cites W4254598990 @default.
• W2000106816 cites W53784274 @default.
• W2000106816 doi "https://doi.org/10.1038/oby.2003.163" @default.
• W2000106816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14569043" @default.
• W2000106816 hasPublicationYear "2003" @default.
• W2000106816 type Work @default.
• W2000106816 sameAs 2000106816 @default.
• W2000106816 citedByCount "138" @default.
• W2000106816 countsByYear W20001068162012 @default.
• W2000106816 countsByYear W20001068162013 @default.
• W2000106816 countsByYear W20001068162014 @default.
• W2000106816 countsByYear W20001068162015 @default.
• W2000106816 countsByYear W20001068162016 @default.
• W2000106816 countsByYear W20001068162017 @default.
• W2000106816 countsByYear W20001068162018 @default.
• W2000106816 countsByYear W20001068162019 @default.
• W2000106816 countsByYear W20001068162020 @default.
• W2000106816 countsByYear W20001068162021 @default.
• W2000106816 countsByYear W20001068162022 @default.
• W2000106816 countsByYear W20001068162023 @default.
• W2000106816 crossrefType "journal-article" @default.
• W2000106816 hasAuthorship W2000106816A5002161503 @default.
• W2000106816 hasAuthorship W2000106816A5009603891 @default.
• W2000106816 hasAuthorship W2000106816A5028599620 @default.
• W2000106816 hasBestOaLocation W20001068161 @default.
• W2000106816 hasConcept C104317684 @default.
• W2000106816 hasConcept C122927707 @default.
• W2000106816 hasConcept C126322002 @default.
• W2000106816 hasConcept C128821507 @default.
• W2000106816 hasConcept C134018914 @default.
• W2000106816 hasConcept C170493617 @default.
• W2000106816 hasConcept C171089720 @default.
• W2000106816 hasConcept C187345961 @default.
• W2000106816 hasConcept C2777391703 @default.
• W2000106816 hasConcept C2779306644 @default.
• W2000106816 hasConcept C55493867 @default.
• W2000106816 hasConcept C63932345 @default.
• W2000106816 hasConcept C71924100 @default.
• W2000106816 hasConcept C86339819 @default.
• W2000106816 hasConcept C86803240 @default.
• W2000106816 hasConceptScore W2000106816C104317684 @default.

• next