FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000108150> ?p ?o ?g. }

• W2000108150 endingPage "1309.e3" @default.
• W2000108150 startingPage "1303" @default.
• W2000108150 abstract "Combined immunodeficiencies (CIDs) form a heterogeneous group of inherited conditions that affect the development, function, or both of T cells. The treatment of CIDs with allogeneic hematopoietic stem cell transplantation (HSCT) is complicated by a high incidence of life-threatening infections and an increased risk of graft-versus-host disease (GVHD).In view of the growing evidence that alloreactivity is mainly derived from human naive T cells, the selective depletion of naive T cells from allografts might constitute a way of reducing alloreactivity while maintaining memory T-cell responsiveness to pathogens.Five consecutive patients with CIDs and chronic viral infections underwent an allogeneic, HLA-mismatched HSCT. Given the patients' infection status and the potential risk of severe GVHD in the mismatched setting, the CD34(-) fraction of the allograft was depleted of naive T cells by using magnetic CD45RA beads.Engraftment occurred in 4 of the 5 patients. No severe GVHD occurred. In the 4 engrafted patients viral infections were cleared within 2 months of the HSCT, and both cellular and humoral immunity were re-established within a year of the HSCT. An early T-cell response against viral pathogens was documented in 2 patients.The present pilot study shows that clinical-grade depletion of naive T cells from an allograft through the use of magnetic CD45RA beads seems to be a feasible and efficacious option for the treatment of patients with CIDs at high risk of GVHD, infection, or both in an HLA-mismatched setting." @default.
• W2000108150 created "2016-06-24" @default.
• W2000108150 creator A5004262241 @default.
• W2000108150 creator A5006102363 @default.
• W2000108150 creator A5007387587 @default.
• W2000108150 creator A5007937004 @default.
• W2000108150 creator A5018645892 @default.
• W2000108150 creator A5028292912 @default.
• W2000108150 creator A5029004287 @default.
• W2000108150 creator A5032698606 @default.
• W2000108150 creator A5051621566 @default.
• W2000108150 creator A5053532327 @default.
• W2000108150 creator A5063790935 @default.
• W2000108150 creator A5068498992 @default.
• W2000108150 creator A5072826939 @default.
• W2000108150 creator A5075374054 @default.
• W2000108150 date "2015-05-01" @default.
• W2000108150 modified "2023-10-01" @default.
• W2000108150 title "CD45RA depletion in HLA-mismatched allogeneic hematopoietic stem cell transplantation for primary combined immunodeficiency: A preliminary study" @default.
• W2000108150 cites W1574493485 @default.
• W2000108150 cites W1988718803 @default.
• W2000108150 cites W2004447909 @default.
• W2000108150 cites W2005251753 @default.
• W2000108150 cites W2010847848 @default.
• W2000108150 cites W2024563150 @default.
• W2000108150 cites W2028887498 @default.
• W2000108150 cites W2033477706 @default.
• W2000108150 cites W2044329467 @default.
• W2000108150 cites W2045470396 @default.
• W2000108150 cites W2048627240 @default.
• W2000108150 cites W2078096787 @default.
• W2000108150 cites W2081953725 @default.
• W2000108150 cites W2086024031 @default.
• W2000108150 cites W2088445779 @default.
• W2000108150 cites W2093964518 @default.
• W2000108150 cites W2095284728 @default.
• W2000108150 cites W2100304556 @default.
• W2000108150 cites W2116168422 @default.
• W2000108150 cites W2165712375 @default.
• W2000108150 cites W4211018908 @default.
• W2000108150 cites W4362204021 @default.
• W2000108150 cites W3151452517 @default.
• W2000108150 doi "https://doi.org/10.1016/j.jaci.2014.08.019" @default.
• W2000108150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25282016" @default.
• W2000108150 hasPublicationYear "2015" @default.
• W2000108150 type Work @default.
• W2000108150 sameAs 2000108150 @default.
• W2000108150 citedByCount "52" @default.
• W2000108150 countsByYear W20001081502015 @default.
• W2000108150 countsByYear W20001081502016 @default.
• W2000108150 countsByYear W20001081502017 @default.
• W2000108150 countsByYear W20001081502018 @default.
• W2000108150 countsByYear W20001081502019 @default.
• W2000108150 countsByYear W20001081502020 @default.
• W2000108150 countsByYear W20001081502021 @default.
• W2000108150 countsByYear W20001081502022 @default.
• W2000108150 countsByYear W20001081502023 @default.
• W2000108150 crossrefType "journal-article" @default.
• W2000108150 hasAuthorship W2000108150A5004262241 @default.
• W2000108150 hasAuthorship W2000108150A5006102363 @default.
• W2000108150 hasAuthorship W2000108150A5007387587 @default.
• W2000108150 hasAuthorship W2000108150A5007937004 @default.
• W2000108150 hasAuthorship W2000108150A5018645892 @default.
• W2000108150 hasAuthorship W2000108150A5028292912 @default.
• W2000108150 hasAuthorship W2000108150A5029004287 @default.
• W2000108150 hasAuthorship W2000108150A5032698606 @default.
• W2000108150 hasAuthorship W2000108150A5051621566 @default.
• W2000108150 hasAuthorship W2000108150A5053532327 @default.
• W2000108150 hasAuthorship W2000108150A5063790935 @default.
• W2000108150 hasAuthorship W2000108150A5068498992 @default.
• W2000108150 hasAuthorship W2000108150A5072826939 @default.
• W2000108150 hasAuthorship W2000108150A5075374054 @default.
• W2000108150 hasConcept C10205521 @default.
• W2000108150 hasConcept C109159458 @default.
• W2000108150 hasConcept C126322002 @default.
• W2000108150 hasConcept C147483822 @default.
• W2000108150 hasConcept C188280979 @default.
• W2000108150 hasConcept C203014093 @default.
• W2000108150 hasConcept C2776090121 @default.
• W2000108150 hasConcept C2777408962 @default.
• W2000108150 hasConcept C2777607303 @default.
• W2000108150 hasConcept C2779972918 @default.
• W2000108150 hasConcept C28328180 @default.
• W2000108150 hasConcept C2911091166 @default.
• W2000108150 hasConcept C54355233 @default.
• W2000108150 hasConcept C71924100 @default.
• W2000108150 hasConcept C86803240 @default.
• W2000108150 hasConcept C8891405 @default.
• W2000108150 hasConceptScore W2000108150C10205521 @default.
• W2000108150 hasConceptScore W2000108150C109159458 @default.
• W2000108150 hasConceptScore W2000108150C126322002 @default.
• W2000108150 hasConceptScore W2000108150C147483822 @default.
• W2000108150 hasConceptScore W2000108150C188280979 @default.
• W2000108150 hasConceptScore W2000108150C203014093 @default.
• W2000108150 hasConceptScore W2000108150C2776090121 @default.
• W2000108150 hasConceptScore W2000108150C2777408962 @default.
• W2000108150 hasConceptScore W2000108150C2777607303 @default.
• W2000108150 hasConceptScore W2000108150C2779972918 @default.

• next