Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000109770> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2000109770 endingPage "1325" @default.
- W2000109770 startingPage "1320" @default.
- W2000109770 abstract "New 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives were prepared and tested as 5-HT3 receptor antagonists. Some of the new compounds antagonized the effect of 5-HT at the longitudinal muscle myenteric plexus (LMMP) preparation of the guinea pig ileum, and two benzothiazole derivatives, compounds 2e and 2f, were more potent than ondansetron in this regard. However, these two compounds were much weaker than the typical 5-HT3 receptor antagonist as displacers of [3H]BRL-43694 binding to rat cerebral cortex homogenates or as antagonists of the bradycardia response to 5-HT in the anaesthetized rat. Like the prokinetic agent cisapride, some of the new compounds enhanced gastric emptying in rats. Compound 2f not only markedly enhanced gastric emptying but was also a potent agonist at the isolated rat oesophageal tunica muscularis mucosae, a preparation sensitive to 5-HT4 receptor stimulation, and enhanced the twitch response in the LMMP preparation. The latter effect was blocked by a high concentration of tropisetron or by previous desensitization with 5-methoxytryptamine. Compound 2f appears to show a promising pharmacological profile as a potential gastrokinetic agent." @default.
- W2000109770 created "2016-06-24" @default.
- W2000109770 creator A5010779664 @default.
- W2000109770 creator A5019453524 @default.
- W2000109770 creator A5045292619 @default.
- W2000109770 creator A5051037144 @default.
- W2000109770 creator A5058549831 @default.
- W2000109770 creator A5068747529 @default.
- W2000109770 creator A5074080484 @default.
- W2000109770 creator A5077624539 @default.
- W2000109770 creator A5090631298 @default.
- W2000109770 date "1994-04-01" @default.
- W2000109770 modified "2023-09-26" @default.
- W2000109770 title "Synthesis of 2-Piperazinylbenzothiazole and 2-Piperazinylbenzoxazole Derivatives with 5-HT3 Antagonist and 5-HT4 Agonist Properties" @default.
- W2000109770 doi "https://doi.org/10.1021/jm00035a012" @default.
- W2000109770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8176710" @default.
- W2000109770 hasPublicationYear "1994" @default.
- W2000109770 type Work @default.
- W2000109770 sameAs 2000109770 @default.
- W2000109770 citedByCount "34" @default.
- W2000109770 countsByYear W20001097702014 @default.
- W2000109770 countsByYear W20001097702015 @default.
- W2000109770 countsByYear W20001097702016 @default.
- W2000109770 countsByYear W20001097702017 @default.
- W2000109770 countsByYear W20001097702019 @default.
- W2000109770 countsByYear W20001097702021 @default.
- W2000109770 crossrefType "journal-article" @default.
- W2000109770 hasAuthorship W2000109770A5010779664 @default.
- W2000109770 hasAuthorship W2000109770A5019453524 @default.
- W2000109770 hasAuthorship W2000109770A5045292619 @default.
- W2000109770 hasAuthorship W2000109770A5051037144 @default.
- W2000109770 hasAuthorship W2000109770A5058549831 @default.
- W2000109770 hasAuthorship W2000109770A5068747529 @default.
- W2000109770 hasAuthorship W2000109770A5074080484 @default.
- W2000109770 hasAuthorship W2000109770A5077624539 @default.
- W2000109770 hasAuthorship W2000109770A5090631298 @default.
- W2000109770 hasConcept C126322002 @default.
- W2000109770 hasConcept C170493617 @default.
- W2000109770 hasConcept C185592680 @default.
- W2000109770 hasConcept C192096249 @default.
- W2000109770 hasConcept C204232928 @default.
- W2000109770 hasConcept C2775864247 @default.
- W2000109770 hasConcept C2776119469 @default.
- W2000109770 hasConcept C2776885963 @default.
- W2000109770 hasConcept C2776907353 @default.
- W2000109770 hasConcept C2777450907 @default.
- W2000109770 hasConcept C2777785214 @default.
- W2000109770 hasConcept C2777960253 @default.
- W2000109770 hasConcept C2778122271 @default.
- W2000109770 hasConcept C2778144076 @default.
- W2000109770 hasConcept C2778938600 @default.
- W2000109770 hasConcept C2779422922 @default.
- W2000109770 hasConcept C3020479747 @default.
- W2000109770 hasConcept C53910766 @default.
- W2000109770 hasConcept C55493867 @default.
- W2000109770 hasConcept C71924100 @default.
- W2000109770 hasConcept C98274493 @default.
- W2000109770 hasConceptScore W2000109770C126322002 @default.
- W2000109770 hasConceptScore W2000109770C170493617 @default.
- W2000109770 hasConceptScore W2000109770C185592680 @default.
- W2000109770 hasConceptScore W2000109770C192096249 @default.
- W2000109770 hasConceptScore W2000109770C204232928 @default.
- W2000109770 hasConceptScore W2000109770C2775864247 @default.
- W2000109770 hasConceptScore W2000109770C2776119469 @default.
- W2000109770 hasConceptScore W2000109770C2776885963 @default.
- W2000109770 hasConceptScore W2000109770C2776907353 @default.
- W2000109770 hasConceptScore W2000109770C2777450907 @default.
- W2000109770 hasConceptScore W2000109770C2777785214 @default.
- W2000109770 hasConceptScore W2000109770C2777960253 @default.
- W2000109770 hasConceptScore W2000109770C2778122271 @default.
- W2000109770 hasConceptScore W2000109770C2778144076 @default.
- W2000109770 hasConceptScore W2000109770C2778938600 @default.
- W2000109770 hasConceptScore W2000109770C2779422922 @default.
- W2000109770 hasConceptScore W2000109770C3020479747 @default.
- W2000109770 hasConceptScore W2000109770C53910766 @default.
- W2000109770 hasConceptScore W2000109770C55493867 @default.
- W2000109770 hasConceptScore W2000109770C71924100 @default.
- W2000109770 hasConceptScore W2000109770C98274493 @default.
- W2000109770 hasIssue "9" @default.
- W2000109770 hasLocation W20001097701 @default.
- W2000109770 hasLocation W20001097702 @default.
- W2000109770 hasOpenAccess W2000109770 @default.
- W2000109770 hasPrimaryLocation W20001097701 @default.
- W2000109770 hasRelatedWork W1978185260 @default.
- W2000109770 hasRelatedWork W1983211936 @default.
- W2000109770 hasRelatedWork W1987187456 @default.
- W2000109770 hasRelatedWork W1989097006 @default.
- W2000109770 hasRelatedWork W1991791282 @default.
- W2000109770 hasRelatedWork W2000109770 @default.
- W2000109770 hasRelatedWork W2055125447 @default.
- W2000109770 hasRelatedWork W2087475735 @default.
- W2000109770 hasRelatedWork W2400767035 @default.
- W2000109770 hasRelatedWork W2412754047 @default.
- W2000109770 hasVolume "37" @default.
- W2000109770 isParatext "false" @default.
- W2000109770 isRetracted "false" @default.
- W2000109770 magId "2000109770" @default.
- W2000109770 workType "article" @default.