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• W2000119781 abstract "<b><i>Aims:</i></b> To investigate health-related quality of life (HRQoL) in short children born small for gestational age (SGA) during growth hormone (GH) treatment and additional postponement of puberty by gonadotropin-releasing hormone analogue (GnRHa). <b><i>Methods:</i></b> HRQoL was studied longitudinally during 2 years of treatment in 97 short SGA children (mean age 11.6 years at start). The children were divided into three groups: prepubertal GH-treated (prep-GH) children, pubertal GH-treated (pub-GH) children, and pubertal GH-treated children with additional GnRHa treatment (pub-GH/GnRHa). HRQoL was measured by generic (TACQOL) and short stature-specific (TACQOL-S) questionnaires. <b><i>Results:</i></b> The TACQOL-S showed that prep-GH children experienced significant HRQoL improvement on the subscales ‘contact with adults’, ‘body image’ and ‘vitality’, and pub-GH/GnRHa children on the subscales ‘contact with adults’, ‘contact with peers’ and ‘physical abilities’. Parents of prep-GH and pub-GH/GnRHa children reported significant HRQoL improvement on most TACQOL-S scales, whereas HRQoL improvement in pub-GH children reached significance for ‘future prospects’ only. The HRQoL gain was similar in the three groups, also after correction for confounders. The generic questionnaire TACQOL did not reveal any changes. <b><i>Conclusions:</i></b> HRQoL improved in prepubertal and pubertal short SGA children during GH treatment. Additional GnRHa treatment had no adverse effect on the HRQoL gain. Disorder-specific questionnaires were particularly appropriate to evaluate HRQoL in children treated for short stature." @default.
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• W2000119781 date "2012-01-01" @default.
• W2000119781 modified "2023-09-26" @default.
• W2000119781 title "Health-Related Quality of Life in Short Children Born Small for Gestational Age: Effects of Growth Hormone Treatment and Postponement of Puberty" @default.
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• W2000119781 doi "https://doi.org/10.1159/000337218" @default.
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