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- W2000119940 abstract "Spermatogenesis is an intricate biological event wherein an undifferentiated spermatogonium develops into mature sperms. MicroRNAs are a type of single strand small non-coding RNA molecule and are implicated in the regulation of many crucial pathways during cell proliferation, apoptosis, and differentiation. Here, we present a comprehensive comparison of miRNA expression profiling in three main stages during porcine spermatogenesis using high-throughput sequencing. We built three small RNA libraries for the testis, the epididymis and the ejaculated sperm from a Landrace boar, and in total obtained 3821 precursor hairpins encoding for 4761 mature miRNAs, of which 23 are miRNA*. Notably, 940 precursor miRNAs produced both the 5’- and 3’- strands as sister pairs, indicating the distinctive expression patterns of germ cell miRNAs. Additionally, 418 out of 710 co-expressed miRNAs were identified as being differentially expressed between libraries (P < 0.001). Apart from the sexual specific X chromosome, many miRNAs were found to be located on chromosome 12, which may play potential roles in spermatogenesis according to the result of synteny analysis with human and mouse. The Gene Ontology and KEGG pathway analysis revealed that the target genes of co-expressed miRNAs were highly involved in the cell cycle process, metal ion binding, modification of plasma membrane, and the p53 signal pathway." @default.
- W2000119940 created "2016-06-24" @default.
- W2000119940 creator A5016113404 @default.
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- W2000119940 creator A5078120636 @default.
- W2000119940 date "2015-01-07" @default.
- W2000119940 modified "2023-10-18" @default.
- W2000119940 title "microRNA profiling in three main stages during porcine spermatogenesis" @default.
- W2000119940 cites W131911175 @default.
- W2000119940 cites W1584433563 @default.
- W2000119940 cites W1920898392 @default.
- W2000119940 cites W1966828612 @default.
- W2000119940 cites W1968421082 @default.
- W2000119940 cites W1969566832 @default.
- W2000119940 cites W1976224782 @default.
- W2000119940 cites W1978682491 @default.
- W2000119940 cites W1985653931 @default.
- W2000119940 cites W1993245361 @default.
- W2000119940 cites W2006077832 @default.
- W2000119940 cites W2006173503 @default.
- W2000119940 cites W2007612364 @default.
- W2000119940 cites W2013868665 @default.
- W2000119940 cites W2016960054 @default.
- W2000119940 cites W2017570593 @default.
- W2000119940 cites W2025309753 @default.
- W2000119940 cites W2031799049 @default.
- W2000119940 cites W2035853871 @default.
- W2000119940 cites W2036959672 @default.
- W2000119940 cites W2038167014 @default.
- W2000119940 cites W2040801294 @default.
- W2000119940 cites W2040851473 @default.
- W2000119940 cites W2041482906 @default.
- W2000119940 cites W2048898838 @default.
- W2000119940 cites W2049353645 @default.
- W2000119940 cites W2050138691 @default.
- W2000119940 cites W2052857919 @default.
- W2000119940 cites W2057283018 @default.
- W2000119940 cites W2057359773 @default.
- W2000119940 cites W2057606871 @default.
- W2000119940 cites W2062573998 @default.
- W2000119940 cites W2065822678 @default.
- W2000119940 cites W2072177313 @default.
- W2000119940 cites W2074629755 @default.
- W2000119940 cites W2077114538 @default.
- W2000119940 cites W2081990324 @default.
- W2000119940 cites W2082213106 @default.
- W2000119940 cites W2083158631 @default.
- W2000119940 cites W2083381199 @default.
- W2000119940 cites W2084560403 @default.
- W2000119940 cites W2087061250 @default.
- W2000119940 cites W2094289110 @default.
- W2000119940 cites W2099408089 @default.
- W2000119940 cites W2100975741 @default.
- W2000119940 cites W2101374289 @default.
- W2000119940 cites W2106645970 @default.
- W2000119940 cites W2109155259 @default.
- W2000119940 cites W2112880435 @default.
- W2000119940 cites W2114037340 @default.
- W2000119940 cites W2119337308 @default.
- W2000119940 cites W2121487483 @default.
- W2000119940 cites W2121599969 @default.
- W2000119940 cites W2121955811 @default.
- W2000119940 cites W2122713520 @default.
- W2000119940 cites W2123214754 @default.
- W2000119940 cites W2124070731 @default.
- W2000119940 cites W2124488916 @default.
- W2000119940 cites W2128879108 @default.
- W2000119940 cites W2128989640 @default.
- W2000119940 cites W2129119890 @default.
- W2000119940 cites W2131581981 @default.
- W2000119940 cites W2133943800 @default.
- W2000119940 cites W2136154089 @default.
- W2000119940 cites W2138266153 @default.
- W2000119940 cites W2140694202 @default.
- W2000119940 cites W2140935534 @default.
- W2000119940 cites W2143875754 @default.
- W2000119940 cites W2144154026 @default.
- W2000119940 cites W2149146453 @default.
- W2000119940 cites W2149523313 @default.
- W2000119940 cites W2151912077 @default.
- W2000119940 cites W2151922790 @default.
- W2000119940 cites W2158199642 @default.
- W2000119940 cites W2161593116 @default.
- W2000119940 cites W2162303379 @default.
- W2000119940 cites W2162674813 @default.
- W2000119940 cites W2171230529 @default.
- W2000119940 cites W2171831215 @default.
- W2000119940 cites W4241390636 @default.
- W2000119940 doi "https://doi.org/10.1007/s10815-014-0406-x" @default.
- W2000119940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4363228" @default.