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- W2000121889 abstract "A new assay for drug metabolism in isolated rat hepatocytes is described. 2,6-Dichloro-4-nitroanisole is O-demethylated to the corresponding phenol. The product, 2,6-dichloro-4-nitrophenol is not further metabolized by the hepatocytes, but accumulates in the extracellular medium. It has a low pKa; thus the strong colour is pH-insensitive in physiological solutions. The assay involves direct spectrophotometric determination of the product in the medium. The reaction is catalyzed by enzymes present in the microsomal fraction, is dependent on oxygen and NADPH, and it is inhibited by carbon monoxide. The equimolar production of formaldehyde is demonstrated. The results indicate that cytochrome P450 is involved in the reaction." @default.
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- W2000121889 title "Dichloro-p-nitroanisole O-demethylase—A convenient assay for microsomal mixed function oxidase in isolated rat hepatocytes" @default.
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- W2000121889 doi "https://doi.org/10.1016/0006-2952(78)90440-9" @default.
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