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- W2000127979 abstract "We aim to evaluate, in a meta-analysis, the ability of CEUS hepatic-vein arrival time (HVAT) in predicting liver cirrhosis, stressing out differences between patients with viral hepatitis B (VHB) and viral hepatitis C (VHC) liver diseases. We reviewed for inclusion studies which assessed the diagnostic performance of contrast-enhanced HVAT and used Sonovue® in patients having unequivocal clinical signs or liver biopsy findings of viral B or C cirrhosis. After testing for variability of the diagnostic threshold, the summary receiver operating characteristic curves (sROC) were constructed and pooled weighted estimates of sensitivity (Se%) and specificity (Sp%) were calculated. Using a random-effects model, meta-regression was performed to explore sources of heterogeneity. Out of 23 eligible studies, six were included in the meta-analysis. Individual data were analyzed in 279 patients, 162 subjects having VHB (cirrhosis prevalence 47.53%) and 117 patients having VHC (cirrhosis prevalence 22.22%). HVAT in VHC cirrhotic patients was significantly shorter than in VHB cirrhotic patients (16.3±2.1 s vs. 22.6±3.9 s, p < 0.001), with no differences between pooled weighted estimates of sensitivity and specificity for the two groups (Se = 80% and Sp = 83.9% vs. Se = 86.7% and Sp = 88.7%, p>0.001). Variation across studies was 15.2% due to heterogeneity. Contrast-enhanced HVAT has good sensitivity and specificity in predicting liver cirrhosis in both VHB and VHC patients, but with significant differences between diagnostic thresholds." @default.
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- W2000127979 date "2011-08-01" @default.
- W2000127979 modified "2023-10-18" @default.
- W2000127979 title "Meta-Analysis of Contrast-Enhanced Hepatic-Vein Arrival Time in the Diagnosis of Viral B versus Viral C Liver Cirrhosis" @default.
- W2000127979 doi "https://doi.org/10.1016/j.ultrasmedbio.2011.05.477" @default.
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