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• W2000129228 abstract "Experiments were performed on 79 lightly pentobarbital-anesthetized rats. Rats displayed a dose-dependent increase in tail-flick latencies following the injection of dopamine (DA) into the lumbar subarachnoid space through an intrathecal tube. Sulpiride, a D2-subtype receptor antagonist, antagonized the DA-induced analgesia (antinociceptive) effect; while SCH-23390, a D1-subtype receptor antagonist, had no effect even in a higher dose. To further investigate whether the well-known spinal serotonergic, noradrenergic and opioidergic receptor systems were involved in DA-induced antinociception, their antagonists, methysergide, phentolamine, and naloxone were tested respectively. The results showed that phentolamine, but not methysergide or naloxone, could block the DA-induced antinociception. The present data provide evidence that DA exerts antinociceptive effects through D2-subtype dopamine receptor(s) at the spinal level, and that spinal alpha-adrenergic receptors may mediate this effect." @default.
• W2000129228 created "2016-06-24" @default.
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• W2000129228 date "1992-01-01" @default.
• W2000129228 modified "2023-10-13" @default.
• W2000129228 title "D2 dopamine receptor involvement in spinal dopamine-produced antinociception" @default.
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• W2000129228 doi "https://doi.org/10.1016/0024-3205(92)90558-7" @default.
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