FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000135114> ?p ?o ?g. }

• W2000135114 endingPage "762" @default.
• W2000135114 startingPage "745" @default.
• W2000135114 abstract "The signal recognition particle (SRP) targets nascent secretory proteins to the ER, but how and where the SRP assembles is largely unknown. Here we analyze the biogenesis of yeast SRP, which consists of an RNA molecule (scR1) and six proteins, by localizing all its components. Although scR1 is cytoplasmic in wild-type cells, nuclear localization was observed in cells lacking any one of the four SRP “core proteins” Srp14p, Srp21p, Srp68p, or Srp72p. Consistently, a major nucleolar pool was detected for these proteins. Sec65p, on the other hand, was found in both the nucleoplasm and the nucleolus, whereas Srp54p was predominantly cytoplasmic. Import of the core proteins into the nucleolus requires the ribosomal protein import receptors Pse1p and Kap123p/Yrb4p, which might, thus, constitute a nucleolar import pathway. Nuclear export of scR1 is mediated by the nuclear export signal receptor Xpo1p, is distinct from mRNA transport, and requires, as evidenced by the nucleolar accumulation of scR1 in a dis3/rrp44 exosome component mutant, an intact scR1 3′ end. A subset of nucleoporins, including Nsp1p and Nup159p (Rat7p), are also necessary for efficient translocation of scR1 from the nucleus to the cytoplasm. We propose that assembly of the SRP requires import of all SRP core proteins into the nucleolus, where they assemble into a pre-SRP with scR1. This particle can then be targeted to the nuclear pores and is subsequently exported to the cytoplasm in an Xpo1p-dependent way." @default.
• W2000135114 created "2016-06-24" @default.
• W2000135114 creator A5041911427 @default.
• W2000135114 creator A5057468179 @default.
• W2000135114 creator A5072895235 @default.
• W2000135114 creator A5083606668 @default.
• W2000135114 date "2001-05-07" @default.
• W2000135114 modified "2023-09-23" @default.
• W2000135114 title "Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export" @default.
• W2000135114 cites W101572434 @default.
• W2000135114 cites W1421420331 @default.
• W2000135114 cites W1485727061 @default.
• W2000135114 cites W1490035592 @default.
• W2000135114 cites W1508541438 @default.
• W2000135114 cites W1515930873 @default.
• W2000135114 cites W1521764524 @default.
• W2000135114 cites W1522596503 @default.
• W2000135114 cites W1524542249 @default.
• W2000135114 cites W1550417488 @default.
• W2000135114 cites W1811811248 @default.
• W2000135114 cites W1916946291 @default.
• W2000135114 cites W1966521400 @default.
• W2000135114 cites W1970711633 @default.
• W2000135114 cites W1971531897 @default.
• W2000135114 cites W1973052124 @default.
• W2000135114 cites W1975749924 @default.
• W2000135114 cites W1979308514 @default.
• W2000135114 cites W1985841255 @default.
• W2000135114 cites W1989650768 @default.
• W2000135114 cites W1991001046 @default.
• W2000135114 cites W1994148031 @default.
• W2000135114 cites W1994234356 @default.
• W2000135114 cites W1995594620 @default.
• W2000135114 cites W1998564815 @default.
• W2000135114 cites W2000992306 @default.
• W2000135114 cites W2005855998 @default.
• W2000135114 cites W2008759181 @default.
• W2000135114 cites W2017284082 @default.
• W2000135114 cites W2018232440 @default.
• W2000135114 cites W2020803942 @default.
• W2000135114 cites W2024237172 @default.
• W2000135114 cites W2031405388 @default.
• W2000135114 cites W2032109985 @default.
• W2000135114 cites W2040232267 @default.
• W2000135114 cites W2044386270 @default.
• W2000135114 cites W2049157126 @default.
• W2000135114 cites W2051567211 @default.
• W2000135114 cites W2055099935 @default.
• W2000135114 cites W2060908886 @default.
• W2000135114 cites W2064639895 @default.
• W2000135114 cites W2066835429 @default.
• W2000135114 cites W2068616417 @default.
• W2000135114 cites W2068910764 @default.
• W2000135114 cites W2069863901 @default.
• W2000135114 cites W2070905857 @default.
• W2000135114 cites W2072185974 @default.
• W2000135114 cites W2073462419 @default.
• W2000135114 cites W2078724625 @default.
• W2000135114 cites W2079255995 @default.
• W2000135114 cites W2079441826 @default.
• W2000135114 cites W2083526293 @default.
• W2000135114 cites W2085304899 @default.
• W2000135114 cites W2085905344 @default.
• W2000135114 cites W2090850551 @default.
• W2000135114 cites W2094095762 @default.
• W2000135114 cites W2095615304 @default.
• W2000135114 cites W2100269820 @default.
• W2000135114 cites W2102585686 @default.
• W2000135114 cites W2105271717 @default.
• W2000135114 cites W2105661146 @default.
• W2000135114 cites W2107210402 @default.
• W2000135114 cites W2110580557 @default.
• W2000135114 cites W2111126181 @default.
• W2000135114 cites W2114187223 @default.
• W2000135114 cites W2116177712 @default.
• W2000135114 cites W2120931117 @default.
• W2000135114 cites W2126431396 @default.
• W2000135114 cites W2129232563 @default.
• W2000135114 cites W2132320427 @default.
• W2000135114 cites W2133201628 @default.
• W2000135114 cites W2139728602 @default.
• W2000135114 cites W2140235777 @default.
• W2000135114 cites W2140673402 @default.
• W2000135114 cites W2146393576 @default.
• W2000135114 cites W2147055704 @default.
• W2000135114 cites W2147543837 @default.
• W2000135114 cites W2151298994 @default.
• W2000135114 cites W2155085170 @default.
• W2000135114 cites W2157099873 @default.
• W2000135114 cites W2161718046 @default.
• W2000135114 cites W2165306451 @default.
• W2000135114 cites W2169333620 @default.
• W2000135114 cites W2169597956 @default.
• W2000135114 cites W2188699195 @default.
• W2000135114 cites W2404132321 @default.
• W2000135114 cites W245827105 @default.
• W2000135114 cites W308604711 @default.
• W2000135114 doi "https://doi.org/10.1083/jcb.153.4.745" @default.

• next