FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000139554> ?p ?o ?g. }

• W2000139554 endingPage "202" @default.
• W2000139554 startingPage "194" @default.
• W2000139554 abstract "Gastrointestinal nematodes are a major problem for pastoral ruminant production systems. This problem could be reduced by the application of breeding strategies that select for nematode resistant sheep, but no suitable molecular markers are available. Research selection flocks containing lines that are resistant (R) or susceptible (S) to gastrointestinal nematodes provide an excellent resource for discovering selectable markers, and for studying the underlying mechanisms of an effective anti-nematode response. In this study we have used a combination of quantitative real time PCR assays and ELISA to determine if nematode challenge impacts on the expression of the satiety-regulating hormone ghrelin. The expression responses were then compared between the selection flock R and S lines. The results show that the basal levels of ghrelin in plasma were greater than 2-fold higher in nematode naïve S line sheep. Three days after a primary nematode challenge divergent ghrelin expression patterns were observed between the selection lines, with levels increasing in R sheep while decreasing in S sheep. After a secondary challenge this trend was repeated, but following a third challenge ghrelin expression levels rose in both R and S sheep, by which time the S animals had acquired an effective immune response to the nematodes, as measured by a significant reduction in faecal egg output. Importantly, this phenomenon was observed in gene expression studies in gut tissues and also in ELISA measurements of ghrelin peptide levels in plasma. A regression analysis showed that ghrelin transcript expression in the gut accounted for >40% of the variation in faecal egg count measured following Haemonchus or Trichostrongylus infection. We therefore hypothesise that the direction of ghrelin expression (up or down) immediately following nematode exposure may play an important role in regulating the differing anti-nematode responses that occur in the R and S lines. Such differences identify ghrelin as a previously unrecognized factor influencing the acquisition of immunity to nematodes." @default.
• W2000139554 created "2016-06-24" @default.
• W2000139554 creator A5014619140 @default.
• W2000139554 creator A5036838363 @default.
• W2000139554 creator A5061233947 @default.
• W2000139554 creator A5065731602 @default.
• W2000139554 creator A5074319488 @default.
• W2000139554 creator A5077848727 @default.
• W2000139554 date "2011-09-01" @default.
• W2000139554 modified "2023-10-10" @default.
• W2000139554 title "Divergent ghrelin expression patterns in sheep genetically resistant or susceptible to gastrointestinal nematodes" @default.
• W2000139554 cites W1567136174 @default.
• W2000139554 cites W1873439505 @default.
• W2000139554 cites W1971115798 @default.
• W2000139554 cites W1975554506 @default.
• W2000139554 cites W2016737577 @default.
• W2000139554 cites W2025207235 @default.
• W2000139554 cites W2026671563 @default.
• W2000139554 cites W2031511019 @default.
• W2000139554 cites W2034821533 @default.
• W2000139554 cites W2044115976 @default.
• W2000139554 cites W2048571290 @default.
• W2000139554 cites W2048876932 @default.
• W2000139554 cites W2063657647 @default.
• W2000139554 cites W2073857965 @default.
• W2000139554 cites W2074601711 @default.
• W2000139554 cites W2090128247 @default.
• W2000139554 cites W2099375765 @default.
• W2000139554 cites W2100094260 @default.
• W2000139554 cites W2100600244 @default.
• W2000139554 cites W2111536564 @default.
• W2000139554 cites W2136724741 @default.
• W2000139554 cites W2137575287 @default.
• W2000139554 cites W2153158958 @default.
• W2000139554 cites W2156196925 @default.
• W2000139554 cites W2157049105 @default.
• W2000139554 cites W2163865122 @default.
• W2000139554 cites W2165178639 @default.
• W2000139554 doi "https://doi.org/10.1016/j.vetpar.2011.05.007" @default.
• W2000139554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21640486" @default.
• W2000139554 hasPublicationYear "2011" @default.
• W2000139554 type Work @default.
• W2000139554 sameAs 2000139554 @default.
• W2000139554 citedByCount "9" @default.
• W2000139554 countsByYear W20001395542012 @default.
• W2000139554 countsByYear W20001395542013 @default.
• W2000139554 countsByYear W20001395542014 @default.
• W2000139554 countsByYear W20001395542016 @default.
• W2000139554 crossrefType "journal-article" @default.
• W2000139554 hasAuthorship W2000139554A5014619140 @default.
• W2000139554 hasAuthorship W2000139554A5036838363 @default.
• W2000139554 hasAuthorship W2000139554A5061233947 @default.
• W2000139554 hasAuthorship W2000139554A5065731602 @default.
• W2000139554 hasAuthorship W2000139554A5074319488 @default.
• W2000139554 hasAuthorship W2000139554A5077848727 @default.
• W2000139554 hasConcept C134018914 @default.
• W2000139554 hasConcept C134215735 @default.
• W2000139554 hasConcept C18903297 @default.
• W2000139554 hasConcept C2778830712 @default.
• W2000139554 hasConcept C2779357093 @default.
• W2000139554 hasConcept C2779825395 @default.
• W2000139554 hasConcept C2781269127 @default.
• W2000139554 hasConcept C71315377 @default.
• W2000139554 hasConcept C86803240 @default.
• W2000139554 hasConceptScore W2000139554C134018914 @default.
• W2000139554 hasConceptScore W2000139554C134215735 @default.
• W2000139554 hasConceptScore W2000139554C18903297 @default.
• W2000139554 hasConceptScore W2000139554C2778830712 @default.
• W2000139554 hasConceptScore W2000139554C2779357093 @default.
• W2000139554 hasConceptScore W2000139554C2779825395 @default.
• W2000139554 hasConceptScore W2000139554C2781269127 @default.
• W2000139554 hasConceptScore W2000139554C71315377 @default.
• W2000139554 hasConceptScore W2000139554C86803240 @default.
• W2000139554 hasIssue "2-4" @default.
• W2000139554 hasLocation W20001395541 @default.
• W2000139554 hasLocation W20001395542 @default.
• W2000139554 hasOpenAccess W2000139554 @default.
• W2000139554 hasPrimaryLocation W20001395541 @default.
• W2000139554 hasRelatedWork W1161177104 @default.
• W2000139554 hasRelatedWork W1973374784 @default.
• W2000139554 hasRelatedWork W2016737577 @default.
• W2000139554 hasRelatedWork W2034821533 @default.
• W2000139554 hasRelatedWork W2097866105 @default.
• W2000139554 hasRelatedWork W2103504334 @default.
• W2000139554 hasRelatedWork W2117248597 @default.
• W2000139554 hasRelatedWork W2144999905 @default.
• W2000139554 hasRelatedWork W2290131406 @default.
• W2000139554 hasRelatedWork W2396814881 @default.
• W2000139554 hasRelatedWork W2564310266 @default.
• W2000139554 hasRelatedWork W2582414771 @default.
• W2000139554 hasRelatedWork W2604757209 @default.
• W2000139554 hasRelatedWork W2923333808 @default.
• W2000139554 hasRelatedWork W3010795462 @default.
• W2000139554 hasRelatedWork W3196078369 @default.
• W2000139554 hasRelatedWork W3204336312 @default.
• W2000139554 hasRelatedWork W3205077223 @default.
• W2000139554 hasRelatedWork W2091324602 @default.
• W2000139554 hasRelatedWork W3146357521 @default.

• next