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- W2000139667 abstract "Lasonolide A is a novel polyketide displaying potent anticancer activity across a broad range of cancer cell lines. Here, an enantioselective convergent total synthesis of the (-)-lasonolide A in 16 longest linear and 34 total steps is described. This approach significantly reduces the step count compared to other known syntheses. The synthetic strategy utilizes alkyne-bearing substrates as core building blocks and is highlighted by stitching together two similarly complex halves via a key Ru-catalyzed alkene-alkyne coupling and macrolactionization." @default.
- W2000139667 created "2016-06-24" @default.
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- W2000139667 date "2013-12-24" @default.
- W2000139667 modified "2023-10-02" @default.
- W2000139667 title "A Concise Synthesis of (−)-Lasonolide A" @default.
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- W2000139667 doi "https://doi.org/10.1021/ja411270d" @default.
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