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• W2000144844 endingPage "e5884" @default.
• W2000144844 startingPage "e5884" @default.
• W2000144844 abstract "Malignant Pleural Effusions (MPE) may be useful as a model to study hierarchical progression of cancer and/or intratumoral heterogeneity. To strengthen the rationale for developing the MPE-model for these purposes, we set out to find evidence for the presence of cancer stem cells (CSC) in MPE and demonstrate an ability to sustain intratumoral heterogeneity in MPE-primary cultures. Our studies show that candidate lung CSC-expression signatures (PTEN, OCT4, hTERT, Bmi1, EZH2 and SUZ12) are evident in cell pellets isolated from MPE, and MPE-cytopathology also labels candidate-CSC (CD44, cMET, MDR-1, ALDH) subpopulations. Moreover, in primary cultures that use MPE as the source of both tumor cells and the tumor microenvironment (TME), candidate CSC are maintained over time. This allows us to live-sort candidate CSC-fractions from the MPE-tumor mix on the basis of surface markers (CD44, c-MET, uPAR, MDR-1) or differences in xenobiotic metabolism (ALDH). Thus, MPE-primary cultures provide an avenue to extract candidate CSC populations from individual (isogenic) MPE-tumors. This will allow us to test whether these cells can be discriminated in functional bioassays. Tumor heterogeneity in MPE-primary cultures is evidenced by variable immunolabeling, differences in colony-morphology, and differences in proliferation rates of cell subpopulations. Collectively, these data justify the ongoing development of the MPE-model for the investigation of intratumoral heterogeneity, tumor-TME interactions, and phenotypic validation of candidate lung CSC, in addition to providing direction for the pre-clinical development of rational therapeutics." @default.
• W2000144844 created "2016-06-24" @default.
• W2000144844 creator A5025885077 @default.
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• W2000144844 date "2009-06-12" @default.
• W2000144844 modified "2023-10-14" @default.
• W2000144844 title "The Malignant Pleural Effusion as a Model to Investigate Intratumoral Heterogeneity in Lung Cancer" @default.
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• W2000144844 doi "https://doi.org/10.1371/journal.pone.0005884" @default.
• W2000144844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2697051" @default.
• W2000144844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19536353" @default.
• W2000144844 hasPublicationYear "2009" @default.
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