FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000147806> ?p ?o ?g. }

• W2000147806 endingPage "298" @default.
• W2000147806 startingPage "288" @default.
• W2000147806 abstract "The fragile X mental retardation 1 (FMR1) gene plays an important role in the development and maintenance of neuronal circuits that are essential for cognitive functioning. We explored the functional linkage(s) among lymphocytic FMR1 gene expression, brain structure, and working memory in healthy adult males. We acquired T1-weighted and diffusion tensor imaging from 37 males (18-80 years, mean ± SD= 40.7 ± 17.3 years) with normal FMR1 alleles and performed genetic and working memory assessments. Brain measurements were obtained from fiber tracts important for working memory (i.e. the arcuate fasciculus, anterior cingulum bundle, inferior longitudinal fasciculus, and the genu and anterior body of the corpus callosum), individual voxels, and whole brain. Both FMR1 mRNA and protein (FMRP) levels exhibited significant associations with brain measurements, with FMRP correlating positively with gray matter volume and white matter structural organization, and FMR1 mRNA negatively with white matter structural organization. The correlation was widespread, impacting rostral white matter and 2 working-memory fiber tracts for FMRP, and all cerebral white matter areas except the fornix and cerebellar peduncles and all 4 fiber tracts for FMR1 mRNA. In addition, the levels of FMR1 mRNA as well as the fiber tracts demonstrated a significant correlation with working memory performance. While FMR1 mRNA exhibited a negative correlation with working memory, fiber tract structural organization showed a positive correlation. These findings suggest that the FMR1 gene is a genetic factor common for both working memory and brain structure, and has implications for our understanding of the transmission of intelligence and brain structure." @default.
• W2000147806 created "2016-06-24" @default.
• W2000147806 creator A5015869563 @default.
• W2000147806 creator A5021259963 @default.
• W2000147806 creator A5026643150 @default.
• W2000147806 creator A5026968101 @default.
• W2000147806 creator A5061384110 @default.
• W2000147806 creator A5074856937 @default.
• W2000147806 creator A5082090045 @default.
• W2000147806 creator A5086196058 @default.
• W2000147806 date "2013-01-01" @default.
• W2000147806 modified "2023-10-18" @default.
• W2000147806 title "Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles" @default.
• W2000147806 cites W1607753434 @default.
• W2000147806 cites W1974333114 @default.
• W2000147806 cites W1985501728 @default.
• W2000147806 cites W1986269945 @default.
• W2000147806 cites W1986949547 @default.
• W2000147806 cites W1991568270 @default.
• W2000147806 cites W2002780348 @default.
• W2000147806 cites W2005078842 @default.
• W2000147806 cites W2012322293 @default.
• W2000147806 cites W2015391962 @default.
• W2000147806 cites W2028109707 @default.
• W2000147806 cites W2028942474 @default.
• W2000147806 cites W2038138414 @default.
• W2000147806 cites W2041527603 @default.
• W2000147806 cites W2042795854 @default.
• W2000147806 cites W2047152236 @default.
• W2000147806 cites W2050703831 @default.
• W2000147806 cites W2052031191 @default.
• W2000147806 cites W2052326665 @default.
• W2000147806 cites W2052758289 @default.
• W2000147806 cites W2053460771 @default.
• W2000147806 cites W2054091111 @default.
• W2000147806 cites W2055831303 @default.
• W2000147806 cites W2059208184 @default.
• W2000147806 cites W2063001897 @default.
• W2000147806 cites W2071482305 @default.
• W2000147806 cites W2071881327 @default.
• W2000147806 cites W2072923434 @default.
• W2000147806 cites W2075344525 @default.
• W2000147806 cites W2081237186 @default.
• W2000147806 cites W2082184485 @default.
• W2000147806 cites W2082226170 @default.
• W2000147806 cites W2082626989 @default.
• W2000147806 cites W2095235225 @default.
• W2000147806 cites W2096905317 @default.
• W2000147806 cites W2098674659 @default.
• W2000147806 cites W2099064674 @default.
• W2000147806 cites W2101609880 @default.
• W2000147806 cites W2102391253 @default.
• W2000147806 cites W2103822617 @default.
• W2000147806 cites W2104346867 @default.
• W2000147806 cites W2111554398 @default.
• W2000147806 cites W2116276594 @default.
• W2000147806 cites W2117973743 @default.
• W2000147806 cites W2119450847 @default.
• W2000147806 cites W2124286401 @default.
• W2000147806 cites W2130616317 @default.
• W2000147806 cites W2130887634 @default.
• W2000147806 cites W2134063049 @default.
• W2000147806 cites W2134222712 @default.
• W2000147806 cites W2134571041 @default.
• W2000147806 cites W2135389676 @default.
• W2000147806 cites W2136649566 @default.
• W2000147806 cites W2137145004 @default.
• W2000147806 cites W2137464920 @default.
• W2000147806 cites W2138695073 @default.
• W2000147806 cites W2139158372 @default.
• W2000147806 cites W2141650732 @default.
• W2000147806 cites W2143347806 @default.
• W2000147806 cites W2144679794 @default.
• W2000147806 cites W2145103394 @default.
• W2000147806 cites W2145132952 @default.
• W2000147806 cites W2145626860 @default.
• W2000147806 cites W2149919973 @default.
• W2000147806 cites W2150667092 @default.
• W2000147806 cites W2153633867 @default.
• W2000147806 cites W2156508673 @default.
• W2000147806 cites W2156866863 @default.
• W2000147806 cites W2162686750 @default.
• W2000147806 cites W2170083175 @default.
• W2000147806 cites W2222966494 @default.
• W2000147806 cites W2240035754 @default.
• W2000147806 cites W2296621543 @default.
• W2000147806 cites W4376595444 @default.
• W2000147806 doi "https://doi.org/10.1016/j.neuroimage.2012.09.075" @default.
• W2000147806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3540208" @default.
• W2000147806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23063447" @default.
• W2000147806 hasPublicationYear "2013" @default.
• W2000147806 type Work @default.
• W2000147806 sameAs 2000147806 @default.
• W2000147806 citedByCount "31" @default.
• W2000147806 countsByYear W20001478062013 @default.
• W2000147806 countsByYear W20001478062014 @default.
• W2000147806 countsByYear W20001478062015 @default.
• W2000147806 countsByYear W20001478062016 @default.

• next