FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000148090> ?p ?o ?g. }

• W2000148090 endingPage "450" @default.
• W2000148090 startingPage "446" @default.
• W2000148090 abstract "The oral administration of indole-3-carbinol (IC), present in cabbage and other members of the Cruciferae family, to female rats almost doubled their ability to convert estradiol to catechol estrogens in the liver. This was determined by the release of 3 H from C-2 of the estrogen and also by isolation of the 14 C-labeled catechol derivative after incubation with hepatic microsomal fractions. The yield of 4-hydroxy estradiol was also elevated and these effects were similar to those produced by 3-methylcholanthrene (MC), a well-characterized cytochrome P450 inducer. Further evidence for the involvement of a mixed-function oxidase was provided by a 70% to 80% decrease in the yield of 3 H 2 O and watersoluble radioactivity by SKF-525A (0.1 mM) when added to the microsomal fractions isolated from the livers of control or IC-treated rats. In addition, NADPH could not be replaced by NADH in these experiments. Pretreatment with ethionine prevented the increase in estradiol metabolism brought about by oral administration of IC. Both IC and MC inhibited catechol estrogen formation when added directly to the liver microsomal system, confirming earlier findings that in vivo inducers can act as in vitro inhibitors. However, IC was less inhibitory than MC, supporting the theory that IC is converted to a more active product in the stomach. Thus, IC may be conferring protection against estrogen-dependent neoplasia by increasing the hepatic oxidation of estradiol, thereby lowering the amount of available active estrogen. (Steroids 56 :446–450, 1991)" @default.
• W2000148090 created "2016-06-24" @default.
• W2000148090 creator A5039328210 @default.
• W2000148090 creator A5053669655 @default.
• W2000148090 creator A5061284569 @default.
• W2000148090 date "1991-08-01" @default.
• W2000148090 modified "2023-09-25" @default.
• W2000148090 title "Influence of indole-3-carbinol on the hepatic microsomal formation of catechol estrogens" @default.
• W2000148090 cites W1500814526 @default.
• W2000148090 cites W1510596518 @default.
• W2000148090 cites W1577465777 @default.
• W2000148090 cites W1775749144 @default.
• W2000148090 cites W1885172001 @default.
• W2000148090 cites W188844480 @default.
• W2000148090 cites W1981126660 @default.
• W2000148090 cites W1986538794 @default.
• W2000148090 cites W1995617105 @default.
• W2000148090 cites W1997367900 @default.
• W2000148090 cites W2000871998 @default.
• W2000148090 cites W2006220416 @default.
• W2000148090 cites W2012776119 @default.
• W2000148090 cites W2020192961 @default.
• W2000148090 cites W2022339251 @default.
• W2000148090 cites W2040016346 @default.
• W2000148090 cites W2045045216 @default.
• W2000148090 cites W2050060522 @default.
• W2000148090 cites W2051255386 @default.
• W2000148090 cites W2061876223 @default.
• W2000148090 cites W2064587136 @default.
• W2000148090 cites W2082876723 @default.
• W2000148090 cites W2089001391 @default.
• W2000148090 cites W2108572185 @default.
• W2000148090 cites W2131017167 @default.
• W2000148090 cites W2132927623 @default.
• W2000148090 cites W2202639174 @default.
• W2000148090 doi "https://doi.org/10.1016/0039-128x(91)90034-s" @default.
• W2000148090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1664992" @default.
• W2000148090 hasPublicationYear "1991" @default.
• W2000148090 type Work @default.
• W2000148090 sameAs 2000148090 @default.
• W2000148090 citedByCount "40" @default.
• W2000148090 countsByYear W20001480902012 @default.
• W2000148090 countsByYear W20001480902014 @default.
• W2000148090 countsByYear W20001480902019 @default.
• W2000148090 crossrefType "journal-article" @default.
• W2000148090 hasAuthorship W2000148090A5039328210 @default.
• W2000148090 hasAuthorship W2000148090A5053669655 @default.
• W2000148090 hasAuthorship W2000148090A5061284569 @default.
• W2000148090 hasConcept C126322002 @default.
• W2000148090 hasConcept C134018914 @default.
• W2000148090 hasConcept C150903083 @default.
• W2000148090 hasConcept C181199279 @default.
• W2000148090 hasConcept C185592680 @default.
• W2000148090 hasConcept C192527728 @default.
• W2000148090 hasConcept C207001950 @default.
• W2000148090 hasConcept C25642318 @default.
• W2000148090 hasConcept C2777164284 @default.
• W2000148090 hasConcept C2777713698 @default.
• W2000148090 hasConcept C2778656385 @default.
• W2000148090 hasConcept C38485361 @default.
• W2000148090 hasConcept C526171541 @default.
• W2000148090 hasConcept C55493867 @default.
• W2000148090 hasConcept C62231903 @default.
• W2000148090 hasConcept C71924100 @default.
• W2000148090 hasConcept C86803240 @default.
• W2000148090 hasConcept C87644729 @default.
• W2000148090 hasConcept C98274493 @default.
• W2000148090 hasConceptScore W2000148090C126322002 @default.
• W2000148090 hasConceptScore W2000148090C134018914 @default.
• W2000148090 hasConceptScore W2000148090C150903083 @default.
• W2000148090 hasConceptScore W2000148090C181199279 @default.
• W2000148090 hasConceptScore W2000148090C185592680 @default.
• W2000148090 hasConceptScore W2000148090C192527728 @default.
• W2000148090 hasConceptScore W2000148090C207001950 @default.
• W2000148090 hasConceptScore W2000148090C25642318 @default.
• W2000148090 hasConceptScore W2000148090C2777164284 @default.
• W2000148090 hasConceptScore W2000148090C2777713698 @default.
• W2000148090 hasConceptScore W2000148090C2778656385 @default.
• W2000148090 hasConceptScore W2000148090C38485361 @default.
• W2000148090 hasConceptScore W2000148090C526171541 @default.
• W2000148090 hasConceptScore W2000148090C55493867 @default.
• W2000148090 hasConceptScore W2000148090C62231903 @default.
• W2000148090 hasConceptScore W2000148090C71924100 @default.
• W2000148090 hasConceptScore W2000148090C86803240 @default.
• W2000148090 hasConceptScore W2000148090C87644729 @default.
• W2000148090 hasConceptScore W2000148090C98274493 @default.
• W2000148090 hasIssue "8" @default.
• W2000148090 hasLocation W20001480901 @default.
• W2000148090 hasLocation W20001480902 @default.
• W2000148090 hasOpenAccess W2000148090 @default.
• W2000148090 hasPrimaryLocation W20001480901 @default.
• W2000148090 hasRelatedWork W1489680136 @default.
• W2000148090 hasRelatedWork W1621741447 @default.
• W2000148090 hasRelatedWork W1965724412 @default.
• W2000148090 hasRelatedWork W2000148090 @default.
• W2000148090 hasRelatedWork W2003738655 @default.
• W2000148090 hasRelatedWork W2038448150 @default.
• W2000148090 hasRelatedWork W2040680915 @default.

• next