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• W2000151566 abstract "One of the main determinants of lung surfactant function is the complex interplay between its protein and lipid components. The lipid specificity of surfactant protein B (SP-B), however, and the protein's ability to selectively squeeze out lipids, has remained contradictory. In this work we present, for the first time to our knowledge, by means of time-of-flight secondary ion mass spectrometry chemical imaging, a direct evidence for colocalization of SP-B as well as its model peptide KL(4) with negatively charged dipalmitoylphosphatidylglycerol under absolute calcium free conditions. Our results prove that protein/lipid localization depends on the miscibility of all surfactant components, which itself is influenced by subphase ionic conditions. In contrast to our earlier studies reporting SP-B/KL(4) colocalization with zwitterionic dipalmitoylphosphatidylcholine, in the presence of even the smallest traces of calcium, we finally evidence an apparent reversal of protein/lipid mixing behavior upon calcium removal with ethylene diamine tetraacetic acid. In addition, scanning force microscopy measurements reveal that by depleting the subphase from calcium ions the protrusion formation ability of SP-B or KL(4) is not hampered. However, in the case of KL(4), distinct differences in protrusion morphology and height are visible. Our results support the idea that calcium ions act as a miscibility switch in surfactant model systems and probably are one of the major factors steering lipid/protein mixing behavior as well as influencing the protein's protrusion formation ability." @default.
• W2000151566 created "2016-06-24" @default.
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• W2000151566 date "2009-07-01" @default.
• W2000151566 modified "2023-09-27" @default.
• W2000151566 title "Calcium Ions as “Miscibility Switch”: Colocalization of Surfactant Protein B with Anionic Lipids under Absolute Calcium Free Conditions" @default.
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• W2000151566 doi "https://doi.org/10.1016/j.bpj.2009.05.011" @default.
• W2000151566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2711324" @default.
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