Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000160226> ?p ?o ?g. }
- W2000160226 endingPage "229" @default.
- W2000160226 startingPage "225" @default.
- W2000160226 abstract "The photodynamic action of riboflavin is generally considered to involve the generation of reactive oxygen species, whose production is enhanced when Cu(II) is present in the reaction. In the present study we report that photoactivated riboflavin causes K(+) loss from fresh human red blood cells (RBC) in a time dependent manner. Addition of Cu(II) further enhances the K(+) loss and also leads to significant hemolysis. Riboflavin in a 2:1 stoichiometry with Cu(II) leads to maximum K(+) loss and up to 45% hemolysis. Bathocuproine, a specific Cu(I)-sequestering agent, when present in the reaction, inhibits the hemolysis completely. Free radical scavengers like superoxide dismutase, potassium iodide and mannitol inhibited the hemolysis up to 55% or more. However, thiourea was the most effective scavenger showing 90% inhibition. These results suggest that K(+) leakage and hemolysis of human RBC are basically free radical mediated reactions." @default.
- W2000160226 created "2016-06-24" @default.
- W2000160226 creator A5020193042 @default.
- W2000160226 creator A5034249017 @default.
- W2000160226 creator A5035562150 @default.
- W2000160226 date "2000-10-01" @default.
- W2000160226 modified "2023-09-27" @default.
- W2000160226 title "Hemolysis of human red blood cells by riboflavin-Cu(II) system" @default.
- W2000160226 cites W1533175851 @default.
- W2000160226 cites W1576614076 @default.
- W2000160226 cites W1798026767 @default.
- W2000160226 cites W1816728254 @default.
- W2000160226 cites W1965721150 @default.
- W2000160226 cites W1967570595 @default.
- W2000160226 cites W1968485474 @default.
- W2000160226 cites W1974056424 @default.
- W2000160226 cites W1975588060 @default.
- W2000160226 cites W1988871512 @default.
- W2000160226 cites W1989269258 @default.
- W2000160226 cites W2006284844 @default.
- W2000160226 cites W2011707920 @default.
- W2000160226 cites W2018214505 @default.
- W2000160226 cites W2019190920 @default.
- W2000160226 cites W2019767572 @default.
- W2000160226 cites W2029684018 @default.
- W2000160226 cites W2033803453 @default.
- W2000160226 cites W2034944682 @default.
- W2000160226 cites W2039823537 @default.
- W2000160226 cites W2043043011 @default.
- W2000160226 cites W2049077186 @default.
- W2000160226 cites W2089742974 @default.
- W2000160226 cites W2091071968 @default.
- W2000160226 cites W2092784117 @default.
- W2000160226 cites W2149855017 @default.
- W2000160226 cites W2151692242 @default.
- W2000160226 cites W2412013239 @default.
- W2000160226 cites W7984914 @default.
- W2000160226 doi "https://doi.org/10.1016/s0304-4165(00)00126-4" @default.
- W2000160226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11042388" @default.
- W2000160226 hasPublicationYear "2000" @default.
- W2000160226 type Work @default.
- W2000160226 sameAs 2000160226 @default.
- W2000160226 citedByCount "12" @default.
- W2000160226 countsByYear W20001602262014 @default.
- W2000160226 countsByYear W20001602262015 @default.
- W2000160226 countsByYear W20001602262019 @default.
- W2000160226 countsByYear W20001602262023 @default.
- W2000160226 crossrefType "journal-article" @default.
- W2000160226 hasAuthorship W2000160226A5020193042 @default.
- W2000160226 hasAuthorship W2000160226A5034249017 @default.
- W2000160226 hasAuthorship W2000160226A5035562150 @default.
- W2000160226 hasConcept C139066938 @default.
- W2000160226 hasConcept C178790620 @default.
- W2000160226 hasConcept C185592680 @default.
- W2000160226 hasConcept C203014093 @default.
- W2000160226 hasConcept C2775838275 @default.
- W2000160226 hasConcept C2776155809 @default.
- W2000160226 hasConcept C2776557347 @default.
- W2000160226 hasConcept C2778004101 @default.
- W2000160226 hasConcept C2778445172 @default.
- W2000160226 hasConcept C2779902561 @default.
- W2000160226 hasConcept C2780538656 @default.
- W2000160226 hasConcept C48349386 @default.
- W2000160226 hasConcept C55493867 @default.
- W2000160226 hasConcept C56783068 @default.
- W2000160226 hasConcept C86803240 @default.
- W2000160226 hasConceptScore W2000160226C139066938 @default.
- W2000160226 hasConceptScore W2000160226C178790620 @default.
- W2000160226 hasConceptScore W2000160226C185592680 @default.
- W2000160226 hasConceptScore W2000160226C203014093 @default.
- W2000160226 hasConceptScore W2000160226C2775838275 @default.
- W2000160226 hasConceptScore W2000160226C2776155809 @default.
- W2000160226 hasConceptScore W2000160226C2776557347 @default.
- W2000160226 hasConceptScore W2000160226C2778004101 @default.
- W2000160226 hasConceptScore W2000160226C2778445172 @default.
- W2000160226 hasConceptScore W2000160226C2779902561 @default.
- W2000160226 hasConceptScore W2000160226C2780538656 @default.
- W2000160226 hasConceptScore W2000160226C48349386 @default.
- W2000160226 hasConceptScore W2000160226C55493867 @default.
- W2000160226 hasConceptScore W2000160226C56783068 @default.
- W2000160226 hasConceptScore W2000160226C86803240 @default.
- W2000160226 hasIssue "2-3" @default.
- W2000160226 hasLocation W20001602261 @default.
- W2000160226 hasLocation W20001602262 @default.
- W2000160226 hasOpenAccess W2000160226 @default.
- W2000160226 hasPrimaryLocation W20001602261 @default.
- W2000160226 hasRelatedWork W1592705842 @default.
- W2000160226 hasRelatedWork W1973917388 @default.
- W2000160226 hasRelatedWork W2025263723 @default.
- W2000160226 hasRelatedWork W2062312352 @default.
- W2000160226 hasRelatedWork W2392598180 @default.
- W2000160226 hasRelatedWork W2412317313 @default.
- W2000160226 hasRelatedWork W2465269589 @default.
- W2000160226 hasRelatedWork W4224302476 @default.
- W2000160226 hasRelatedWork W4246573357 @default.
- W2000160226 hasRelatedWork W2598519676 @default.
- W2000160226 hasVolume "1523" @default.
- W2000160226 isParatext "false" @default.