FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000160778> ?p ?o ?g. }

• W2000160778 endingPage "788" @default.
• W2000160778 startingPage "782" @default.
• W2000160778 abstract "Objective: Acute respiratory distress syndrome is an abrupt inflammatory illness that involves damage from reactive oxygen species. We examined the efficacy and safety of oxothiazolidine-4-carboxylic acid (OTZ), a free radical scavenger, in treating acute respiratory distress syndrome. Design: Double-blind, placebo-controlled trial. Setting: Multicentered study. Patients: Patients with a Pao2/Fio2 ≤200 and bilateral infiltrates on chest radiograph, and requiring mechanical ventilation. Interventions: We randomized 215 patients to receive OTZ, 210 mg/kg per day every 8 hrs for 14 days or placebo. Measurements and Main Results: Ventilator-free days (the number of days alive and free from ventilator requirement) during the first 30 days of study were 8.3 vs. 13.5 days for the OTZ and placebo groups, respectively (p < .001). Mortality was 30/101 (29.7%) in the OTZ group and 18/114 (15.8%) in the placebo group during the 30-day study period (p = .014). This study was terminated prematurely for safety reasons after 215 of the planned 352 patients were enrolled. Conclusions: OTZ does not improve survival or reduce ventilator time in patients with acute respiratory distress syndrome and may worsen outcome, although mortality in the OTZ group was similar or lower than most similar trials. Alternatively, our results may be best explained by the unusually excellent outcome in the placebo group." @default.
• W2000160778 created "2016-06-24" @default.
• W2000160778 creator A5000807500 @default.
• W2000160778 creator A5003379719 @default.
• W2000160778 creator A5018214563 @default.
• W2000160778 creator A5033200510 @default.
• W2000160778 creator A5042697024 @default.
• W2000160778 creator A5052393113 @default.
• W2000160778 creator A5075975470 @default.
• W2000160778 creator A5090576091 @default.
• W2000160778 date "2008-03-01" @default.
• W2000160778 modified "2023-10-18" @default.
• W2000160778 title "A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome*" @default.
• W2000160778 cites W1969495917 @default.
• W2000160778 cites W1972146140 @default.
• W2000160778 cites W1973057402 @default.
• W2000160778 cites W1978960863 @default.
• W2000160778 cites W1983881370 @default.
• W2000160778 cites W2005205976 @default.
• W2000160778 cites W2006474258 @default.
• W2000160778 cites W2018624955 @default.
• W2000160778 cites W2029661393 @default.
• W2000160778 cites W2061663169 @default.
• W2000160778 cites W2068854215 @default.
• W2000160778 cites W2071051432 @default.
• W2000160778 cites W2076975458 @default.
• W2000160778 cites W2084580566 @default.
• W2000160778 cites W2089046319 @default.
• W2000160778 cites W2090385997 @default.
• W2000160778 cites W2094764102 @default.
• W2000160778 cites W2103656751 @default.
• W2000160778 cites W2136905084 @default.
• W2000160778 cites W2143748013 @default.
• W2000160778 cites W2265469107 @default.
• W2000160778 cites W2314787815 @default.
• W2000160778 cites W2333620606 @default.
• W2000160778 cites W2597070792 @default.
• W2000160778 cites W33144872 @default.
• W2000160778 doi "https://doi.org/10.1097/ccm.0b013e318164e7e4" @default.
• W2000160778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18209670" @default.
• W2000160778 hasPublicationYear "2008" @default.
• W2000160778 type Work @default.
• W2000160778 sameAs 2000160778 @default.
• W2000160778 citedByCount "35" @default.
• W2000160778 countsByYear W20001607782012 @default.
• W2000160778 countsByYear W20001607782013 @default.
• W2000160778 countsByYear W20001607782017 @default.
• W2000160778 countsByYear W20001607782018 @default.
• W2000160778 countsByYear W20001607782019 @default.
• W2000160778 countsByYear W20001607782020 @default.
• W2000160778 countsByYear W20001607782021 @default.
• W2000160778 countsByYear W20001607782022 @default.
• W2000160778 countsByYear W20001607782023 @default.
• W2000160778 crossrefType "journal-article" @default.
• W2000160778 hasAuthorship W2000160778A5000807500 @default.
• W2000160778 hasAuthorship W2000160778A5003379719 @default.
• W2000160778 hasAuthorship W2000160778A5018214563 @default.
• W2000160778 hasAuthorship W2000160778A5033200510 @default.
• W2000160778 hasAuthorship W2000160778A5042697024 @default.
• W2000160778 hasAuthorship W2000160778A5052393113 @default.
• W2000160778 hasAuthorship W2000160778A5075975470 @default.
• W2000160778 hasAuthorship W2000160778A5090576091 @default.
• W2000160778 hasConcept C126322002 @default.
• W2000160778 hasConcept C141983124 @default.
• W2000160778 hasConcept C142724271 @default.
• W2000160778 hasConcept C168563851 @default.
• W2000160778 hasConcept C204787440 @default.
• W2000160778 hasConcept C27081682 @default.
• W2000160778 hasConcept C2777080012 @default.
• W2000160778 hasConcept C2777714996 @default.
• W2000160778 hasConcept C2781137159 @default.
• W2000160778 hasConcept C2909621147 @default.
• W2000160778 hasConcept C42219234 @default.
• W2000160778 hasConcept C71924100 @default.
• W2000160778 hasConceptScore W2000160778C126322002 @default.
• W2000160778 hasConceptScore W2000160778C141983124 @default.
• W2000160778 hasConceptScore W2000160778C142724271 @default.
• W2000160778 hasConceptScore W2000160778C168563851 @default.
• W2000160778 hasConceptScore W2000160778C204787440 @default.
• W2000160778 hasConceptScore W2000160778C27081682 @default.
• W2000160778 hasConceptScore W2000160778C2777080012 @default.
• W2000160778 hasConceptScore W2000160778C2777714996 @default.
• W2000160778 hasConceptScore W2000160778C2781137159 @default.
• W2000160778 hasConceptScore W2000160778C2909621147 @default.
• W2000160778 hasConceptScore W2000160778C42219234 @default.
• W2000160778 hasConceptScore W2000160778C71924100 @default.
• W2000160778 hasIssue "3" @default.
• W2000160778 hasLocation W20001607781 @default.
• W2000160778 hasLocation W20001607782 @default.
• W2000160778 hasOpenAccess W2000160778 @default.
• W2000160778 hasPrimaryLocation W20001607781 @default.
• W2000160778 hasRelatedWork W1859326399 @default.
• W2000160778 hasRelatedWork W2028715403 @default.
• W2000160778 hasRelatedWork W2075760141 @default.
• W2000160778 hasRelatedWork W2077771712 @default.
• W2000160778 hasRelatedWork W2379971878 @default.
• W2000160778 hasRelatedWork W2385236099 @default.
• W2000160778 hasRelatedWork W2907607950 @default.

• next