Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000166384> ?p ?o ?g. }
- W2000166384 endingPage "348" @default.
- W2000166384 startingPage "348" @default.
- W2000166384 abstract "Stress and anxiety-related behaviors are seen in many organisms. Studies have shown that in humans and other animals, treatment with selective serotonin reuptake inhibitors (e.g. fluoxetine) can reduce anxiety and anxiety-related behaviors. The efficacies and side effects, however, can vary between individuals. Fluoxetine can modulate anxiety in a stereospecific manner or with equal efficacy regardless of stereoisomer depending on the mechanism of action (e.g. serotonergic or GABAergic effects). Zebrafish are an emerging and valuable translational model for understanding human health related issues such as anxiety. In this study we present data showing the behavioral and whole brain transcriptome changes with fluoxetine treatment in wild-derived zebrafish and suggest additional molecular mechanisms of this widely-prescribed drug. We used automated behavioral analyses to assess the effects of racemic and stereoisomeric fluoxetine on male wild-derived zebrafish. Both racemic and the individual isomers of fluoxetine reduced anxiety-related behaviors relative to controls and we did not observe stereospecific fluoxetine effects. Using RNA-sequencing of the whole brain, we identified 411 genes showing differential expression with racemic fluoxetine treatment. Several neuropeptides (neuropeptide Y, isotocin, urocortin 3, prolactin) showed consistent expression patterns with the alleviation of stress and anxiety when anxiety-related behavior was reduced with fluoxetine treatment. With gene ontology and KEGG pathway analyses, we identified lipid and amino acid metabolic processes, and steroid biosynthesis among other terms to be over-enriched. Our results demonstrate that fluoxetine reduces anxiety-related behaviors in wild-derived zebrafish and alters their neurogenomic state. We identify two biological processes, lipid and amino acid metabolic synthesis that characterize differences in the fluoxetine treated fish. Fluoxetine may be acting on several different molecular pathways to reduce anxiety-related behaviors in wild-derived zebrafish. This study provides data that could help identify common molecular mechanisms of fluoxetine action across animal taxa." @default.
- W2000166384 created "2016-06-24" @default.
- W2000166384 creator A5005235905 @default.
- W2000166384 creator A5040786107 @default.
- W2000166384 creator A5051820706 @default.
- W2000166384 date "2013-01-01" @default.
- W2000166384 modified "2023-10-18" @default.
- W2000166384 title "Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment" @default.
- W2000166384 cites W139471607 @default.
- W2000166384 cites W1545745337 @default.
- W2000166384 cites W1572438763 @default.
- W2000166384 cites W1589957162 @default.
- W2000166384 cites W1924375074 @default.
- W2000166384 cites W1966325974 @default.
- W2000166384 cites W1967466543 @default.
- W2000166384 cites W1968631671 @default.
- W2000166384 cites W1972475596 @default.
- W2000166384 cites W1972476800 @default.
- W2000166384 cites W1980043169 @default.
- W2000166384 cites W1980923887 @default.
- W2000166384 cites W1981239255 @default.
- W2000166384 cites W1982238228 @default.
- W2000166384 cites W1983354199 @default.
- W2000166384 cites W1983848110 @default.
- W2000166384 cites W1984232547 @default.
- W2000166384 cites W1985073457 @default.
- W2000166384 cites W1985694975 @default.
- W2000166384 cites W1986380157 @default.
- W2000166384 cites W1987735575 @default.
- W2000166384 cites W1987972424 @default.
- W2000166384 cites W1990029696 @default.
- W2000166384 cites W1993068004 @default.
- W2000166384 cites W1993130604 @default.
- W2000166384 cites W1993578214 @default.
- W2000166384 cites W1993904321 @default.
- W2000166384 cites W1995070233 @default.
- W2000166384 cites W1998087220 @default.
- W2000166384 cites W1998767819 @default.
- W2000166384 cites W1998893802 @default.
- W2000166384 cites W2000805219 @default.
- W2000166384 cites W2002863546 @default.
- W2000166384 cites W2003953346 @default.
- W2000166384 cites W2004611277 @default.
- W2000166384 cites W2004820639 @default.
- W2000166384 cites W2007208508 @default.
- W2000166384 cites W2008833406 @default.
- W2000166384 cites W2009766076 @default.
- W2000166384 cites W2016624695 @default.
- W2000166384 cites W2018831144 @default.
- W2000166384 cites W2019442286 @default.
- W2000166384 cites W2023636464 @default.
- W2000166384 cites W2023756806 @default.
- W2000166384 cites W2024542458 @default.
- W2000166384 cites W2029267980 @default.
- W2000166384 cites W2030314043 @default.
- W2000166384 cites W2031111307 @default.
- W2000166384 cites W2031574974 @default.
- W2000166384 cites W2033521032 @default.
- W2000166384 cites W2034413099 @default.
- W2000166384 cites W2034549511 @default.
- W2000166384 cites W2040529715 @default.
- W2000166384 cites W2041635772 @default.
- W2000166384 cites W2041827294 @default.
- W2000166384 cites W2046063439 @default.
- W2000166384 cites W2046490202 @default.
- W2000166384 cites W2048163734 @default.
- W2000166384 cites W2051012156 @default.
- W2000166384 cites W2054193501 @default.
- W2000166384 cites W2055197182 @default.
- W2000166384 cites W2055926767 @default.
- W2000166384 cites W2055973181 @default.
- W2000166384 cites W2059548283 @default.
- W2000166384 cites W2061912939 @default.
- W2000166384 cites W2063337445 @default.
- W2000166384 cites W2065071991 @default.
- W2000166384 cites W2065574911 @default.
- W2000166384 cites W2067181091 @default.
- W2000166384 cites W2069300470 @default.
- W2000166384 cites W2074261830 @default.
- W2000166384 cites W2078832578 @default.
- W2000166384 cites W2079761961 @default.
- W2000166384 cites W2080402976 @default.
- W2000166384 cites W2088290994 @default.
- W2000166384 cites W2092505944 @default.
- W2000166384 cites W2092835203 @default.
- W2000166384 cites W2093382813 @default.
- W2000166384 cites W2093691975 @default.
- W2000166384 cites W2096441981 @default.
- W2000166384 cites W2097194713 @default.
- W2000166384 cites W2097432914 @default.
- W2000166384 cites W2098662940 @default.
- W2000166384 cites W2099249565 @default.
- W2000166384 cites W2099445531 @default.
- W2000166384 cites W2105356326 @default.
- W2000166384 cites W2105999742 @default.
- W2000166384 cites W2109636493 @default.
- W2000166384 cites W2109812979 @default.
- W2000166384 cites W2114669966 @default.