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• W2000166997 abstract "The aim of this study was to determine the selectivity of (S,S)-2-(α-(2-methoxyphenoxy)benzyl)morpholine (MeNER) binding to norepinephrine transporters (NET). Quantitative autoradiography studies of NET binding were performed in brains of wildtype mice and those of mutant mice lacking one or two alleles of the NET gene. [3H]MeNER binding in the wildtype mouse brains was consistent with previously reported distributions of NET. Highest levels were found in the locus coeruleus, thalamus, hypothalamus, and bed nucleus of stria terminalis. Specific binding in these regions was ˜50% in the heterozygous NET mice and negligible in the NET knockout mice. Binding in the wildtype mouse brains was displaced by the NETligand, nisoxetine, but not by the serotonin or dopamine transporter blockers, citalopram or GBR 12935. [3H]MeNER displayed much higher affinity for NET than for SERT or DAT in homogenate binding studies. Each of these features supports thebinding specificity of this candidate in vivo NET ligand. Synapse 56:100–104, 2005. © 2005 Wiley-Liss, Inc." @default.
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• W2000166997 date "2005-01-01" @default.
• W2000166997 modified "2023-10-04" @default.
• W2000166997 title "Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters" @default.
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• W2000166997 doi "https://doi.org/10.1002/syn.20133" @default.
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