FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000167230> ?p ?o ?g. }

• W2000167230 endingPage "342" @default.
• W2000167230 startingPage "341" @default.
• W2000167230 abstract "Although the first cases of thrombosis following air travel were reported in 1954 by Homans (1), interest has recently heightened. Numerous cases have been reported, but controlled studies are few and contradictory. In a series of patients who had died suddenly at Heathrow Airport, this occurred far more often in the arrival than in the departure area (2). Casecontrol studies have yielded conflicting results, with two French studies showing a two to fourfold increased risk of travel compared to no travel (3;4), while a Dutch (5) and a British study (6) found no elevated risk. A study of severe pulmonary embolism in travellers showed a 50-fold risk gradient with the distance travelled (7), while two studies using ultrasound measurements to detect asymptomatic clots found these in a significant number of travellers (8;9). The Multiple Environmental and Genetic Assessment (MEGA) is an ongoing case-control study aimed at assessing interactive effects of genetic and acquired risk factors for venous thrombosis. Cases are consecutive patients with a first objectively confirmed deep-vein thrombosis (DVT) or pulmonary embolism (PE) registered for anticoagulant treatment at six regional Anticoagulation Clinics. Controls are spouses of of cases. There are no exclusion criteria. Cases and controls fill out a detailed questionnaire, are interviewed in-person, and have venous blood drawn. For the current report, we have data on 829 cases and 829 controls. We considered as travel, any travel of more than 4 hours in two months preceeding the index data. Factor V Leiden (FVL) and prothrombin 20210A (PT20210A) were measured by standard PCR techniques. 465 (56%) patients had DVT, 341 PE (41%). A prothrombotic mutation (FVL or PT20201A) was present in 19.9% of patients and 7.7% of controls (OR=2.9, CI95 1.9-4.3). 112 (13.5%) of patients had travelled in the preceeding two months, for 30 of whom thrombosis was diagnosed within one week after travel. For all modes of travel combined, it increased risk of thrombosis 3-fold (OR=3.1, CI95 1.9-5.1). Plane travel increased risk 6-fold (OR=5.8, CI95 2.0-16.6) and other modes of travel 2-fold (OR 2.2, CI95 1.9-4.3). Individuals with a prothrombotic mutation who travelled by airplane had a 13-fold increased risk compared to individuals without a mutation who did not travel. This joint risk exceeded the sum of the separate risks of flying and mutations. Prolonged travel by car, autobus and airplane is associated with an increased risk of venous thrombosis, with the highest risk for air travel. Individuals with prothrombotic mutations are at higher risk." @default.
• W2000167230 created "2016-06-24" @default.
• W2000167230 creator A5076930387 @default.
• W2000167230 date "2002-01-01" @default.
• W2000167230 modified "2023-09-23" @default.
• W2000167230 title "Air travel and thrombosis" @default.
• W2000167230 cites W1975960450 @default.
• W2000167230 cites W2035923107 @default.
• W2000167230 cites W2048051936 @default.
• W2000167230 cites W2065231049 @default.
• W2000167230 cites W2067086317 @default.
• W2000167230 cites W2087773001 @default.
• W2000167230 cites W2094070926 @default.
• W2000167230 cites W2134299894 @default.
• W2000167230 cites W2407356866 @default.
• W2000167230 doi "https://doi.org/10.1159/000073594" @default.
• W2000167230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13679670" @default.
• W2000167230 hasPublicationYear "2002" @default.
• W2000167230 type Work @default.
• W2000167230 sameAs 2000167230 @default.
• W2000167230 citedByCount "15" @default.
• W2000167230 countsByYear W20001672302013 @default.
• W2000167230 countsByYear W20001672302015 @default.
• W2000167230 countsByYear W20001672302019 @default.
• W2000167230 countsByYear W20001672302020 @default.
• W2000167230 countsByYear W20001672302021 @default.
• W2000167230 countsByYear W20001672302023 @default.
• W2000167230 crossrefType "journal-article" @default.
• W2000167230 hasAuthorship W2000167230A5076930387 @default.
• W2000167230 hasBestOaLocation W20001672301 @default.
• W2000167230 hasConcept C141071460 @default.
• W2000167230 hasConcept C2780868729 @default.
• W2000167230 hasConcept C71924100 @default.
• W2000167230 hasConceptScore W2000167230C141071460 @default.
• W2000167230 hasConceptScore W2000167230C2780868729 @default.
• W2000167230 hasConceptScore W2000167230C71924100 @default.
• W2000167230 hasIssue "5-6" @default.
• W2000167230 hasLocation W20001672301 @default.
• W2000167230 hasLocation W20001672302 @default.
• W2000167230 hasLocation W20001672303 @default.
• W2000167230 hasOpenAccess W2000167230 @default.
• W2000167230 hasPrimaryLocation W20001672301 @default.
• W2000167230 hasRelatedWork W113810927 @default.
• W2000167230 hasRelatedWork W1586374228 @default.
• W2000167230 hasRelatedWork W2003938723 @default.
• W2000167230 hasRelatedWork W2047967234 @default.
• W2000167230 hasRelatedWork W2118496982 @default.
• W2000167230 hasRelatedWork W2364998975 @default.
• W2000167230 hasRelatedWork W2369162477 @default.
• W2000167230 hasRelatedWork W2439875401 @default.
• W2000167230 hasRelatedWork W4238867864 @default.
• W2000167230 hasRelatedWork W2525756941 @default.
• W2000167230 hasVolume "32" @default.
• W2000167230 isParatext "false" @default.
• W2000167230 isRetracted "false" @default.
• W2000167230 magId "2000167230" @default.
• W2000167230 workType "article" @default.