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• W2000170503 abstract "We studied a 17-year-old girl with subacute necrotizing encephalomyelopathy (Leigh syndrome). Lactate and pyruvate levels were increased in serum and cerebrospinal fluid. The oxidation rates of all substrates tested, i.e. pyruvate in liver, and pyruvate, malate and 2-oxoglutarate in muscle, were decreased, as was the production of adenosine triphosphate plus creatine phosphate. Cytochrome content was normal. The data imply a defect in oxidative phosphorylation, outside the cytochrome region." @default.
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• W2000170503 date "2009-01-29" @default.
• W2000170503 modified "2023-10-14" @default.
• W2000170503 title "Subacute necrotizing encephalomyelopathy (Leigh syndrome) associated with disturbed oxidation of pyruvate, malate and 2-oxoglutarate in muscle and liver" @default.
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• W2000170503 doi "https://doi.org/10.1111/j.1600-0404.1985.tb01545.x" @default.
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