Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000171211> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2000171211 endingPage "417" @default.
- W2000171211 startingPage "409" @default.
- W2000171211 abstract "Supercooled smectic cholesterol ester nanoparticles are under investigation as a new carrier system for lipophilic drugs. The smectic thermotropic liquid crystalline state of the matrix lipid is expected to lead to advantages with respect to physicochemical stability and drug loading capacity. Such nanoparticles can be prepared by high-pressure melt homogenization in the presence of emulsifiers. The purpose of this study was to develop PEGylated supercooled smectic cholesteryl myristate nanoparticles for parenteral administration and to provide evidence of the successful PEGylation by detecting the alterations of particle properties due to the insertion of PEGylated phospholipid into the surface layer of the particles. To achieve PEGylation, MPEG(2000)-DSPE was processed together with the phospholipids used as emulsifiers during particle preparation. The influence of the PEGylated phospholipid on the size, zeta potential, phase behavior and recrystallization tendency of the nanoparticles indicated the insertion of MPEG(2000)-DSPE into the surface layer of the particles. Evidence of the PEGylation was also obtained by (1)H NMR measurements, and the steric stabilization was verified by neutralizing the particle surface charge with calcium chloride or adjusting the pH value. As sterility is an important aspect with regard to parenteral administration of the dispersions their stability upon autoclaving was a further point of interest in the present study. The results indicate that PEGylated particles can be sterilized by autoclaving. In conclusion, the PEGylated particles are a promising formulation with respect to small particle size, stability against recrystallization and upon autoclaving." @default.
- W2000171211 created "2016-06-24" @default.
- W2000171211 creator A5043621742 @default.
- W2000171211 creator A5066119699 @default.
- W2000171211 date "2012-06-01" @default.
- W2000171211 modified "2023-10-05" @default.
- W2000171211 title "PEGylation of supercooled smectic cholesteryl myristate nanoparticles" @default.
- W2000171211 cites W1567006673 @default.
- W2000171211 cites W184758871 @default.
- W2000171211 cites W1970239046 @default.
- W2000171211 cites W1980922611 @default.
- W2000171211 cites W1982813079 @default.
- W2000171211 cites W1987027722 @default.
- W2000171211 cites W2007648100 @default.
- W2000171211 cites W2020488747 @default.
- W2000171211 cites W2022384016 @default.
- W2000171211 cites W2038375984 @default.
- W2000171211 cites W2054064143 @default.
- W2000171211 cites W2054189154 @default.
- W2000171211 cites W2067892292 @default.
- W2000171211 cites W2070342688 @default.
- W2000171211 cites W2094444833 @default.
- W2000171211 cites W2119784812 @default.
- W2000171211 cites W2123624166 @default.
- W2000171211 cites W2142788272 @default.
- W2000171211 cites W2161580101 @default.
- W2000171211 cites W230709115 @default.
- W2000171211 doi "https://doi.org/10.1016/j.ejpb.2012.03.011" @default.
- W2000171211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22487056" @default.
- W2000171211 hasPublicationYear "2012" @default.
- W2000171211 type Work @default.
- W2000171211 sameAs 2000171211 @default.
- W2000171211 citedByCount "9" @default.
- W2000171211 countsByYear W20001712112012 @default.
- W2000171211 countsByYear W20001712112013 @default.
- W2000171211 countsByYear W20001712112014 @default.
- W2000171211 countsByYear W20001712112016 @default.
- W2000171211 countsByYear W20001712112019 @default.
- W2000171211 countsByYear W20001712112020 @default.
- W2000171211 countsByYear W20001712112021 @default.
- W2000171211 crossrefType "journal-article" @default.
- W2000171211 hasAuthorship W2000171211A5043621742 @default.
- W2000171211 hasAuthorship W2000171211A5066119699 @default.
- W2000171211 hasConcept C11432220 @default.
- W2000171211 hasConcept C127413603 @default.
- W2000171211 hasConcept C147789679 @default.
- W2000171211 hasConcept C155672457 @default.
- W2000171211 hasConcept C171250308 @default.
- W2000171211 hasConcept C178790620 @default.
- W2000171211 hasConcept C185592680 @default.
- W2000171211 hasConcept C187530423 @default.
- W2000171211 hasConcept C192562407 @default.
- W2000171211 hasConcept C22064058 @default.
- W2000171211 hasConcept C2776964284 @default.
- W2000171211 hasConcept C2779149719 @default.
- W2000171211 hasConcept C2994273327 @default.
- W2000171211 hasConcept C42360764 @default.
- W2000171211 hasConcept C43617362 @default.
- W2000171211 hasConcept C44280652 @default.
- W2000171211 hasConcept C86181022 @default.
- W2000171211 hasConceptScore W2000171211C11432220 @default.
- W2000171211 hasConceptScore W2000171211C127413603 @default.
- W2000171211 hasConceptScore W2000171211C147789679 @default.
- W2000171211 hasConceptScore W2000171211C155672457 @default.
- W2000171211 hasConceptScore W2000171211C171250308 @default.
- W2000171211 hasConceptScore W2000171211C178790620 @default.
- W2000171211 hasConceptScore W2000171211C185592680 @default.
- W2000171211 hasConceptScore W2000171211C187530423 @default.
- W2000171211 hasConceptScore W2000171211C192562407 @default.
- W2000171211 hasConceptScore W2000171211C22064058 @default.
- W2000171211 hasConceptScore W2000171211C2776964284 @default.
- W2000171211 hasConceptScore W2000171211C2779149719 @default.
- W2000171211 hasConceptScore W2000171211C2994273327 @default.
- W2000171211 hasConceptScore W2000171211C42360764 @default.
- W2000171211 hasConceptScore W2000171211C43617362 @default.
- W2000171211 hasConceptScore W2000171211C44280652 @default.
- W2000171211 hasConceptScore W2000171211C86181022 @default.
- W2000171211 hasIssue "2" @default.
- W2000171211 hasLocation W20001712111 @default.
- W2000171211 hasLocation W20001712112 @default.
- W2000171211 hasOpenAccess W2000171211 @default.
- W2000171211 hasPrimaryLocation W20001712111 @default.
- W2000171211 hasRelatedWork W1971645600 @default.
- W2000171211 hasRelatedWork W1997967820 @default.
- W2000171211 hasRelatedWork W2140907237 @default.
- W2000171211 hasRelatedWork W2203584037 @default.
- W2000171211 hasRelatedWork W2352333521 @default.
- W2000171211 hasRelatedWork W2383776710 @default.
- W2000171211 hasRelatedWork W2766482228 @default.
- W2000171211 hasRelatedWork W2808643508 @default.
- W2000171211 hasRelatedWork W3097648928 @default.
- W2000171211 hasRelatedWork W2953936319 @default.
- W2000171211 hasVolume "81" @default.
- W2000171211 isParatext "false" @default.
- W2000171211 isRetracted "false" @default.
- W2000171211 magId "2000171211" @default.
- W2000171211 workType "article" @default.