FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000183088> ?p ?o ?g. }

• W2000183088 endingPage "1742" @default.
• W2000183088 startingPage "1734" @default.
• W2000183088 abstract "At endogenous brain concentrations, the astrocyte-derived metabolite kynurenic acid (KYNA) antagonizes the α7 nicotinic acetylcholine receptor and, possibly, the glycine co-agonist site of the NMDA receptor. The functions of these two receptors, which are intimately involved in synaptic plasticity and cognitive processes, may, therefore, be enhanced by reductions in brain KYNA levels. This concept was tested in mice with a targeted deletion of kynurenine aminotransferase II (KAT II), a major biosynthetic enzyme of brain KYNA. At 21 days of age, KAT II knock-out mice had reduced hippocampal KYNA levels (−71%) and showed significantly increased performance in three cognitive paradigms that rely in part on the integrity of hippocampal function, namely object exploration and recognition, passive avoidance, and spatial discrimination. Moreover, compared with wild-type controls, hippocampal slices from KAT II-deficient mice showed a significant increase in the amplitude of long-term potentiation in vitro. These functional changes were accompanied by reduced extracellular KYNA (−66%) and increased extracellular glutamate (+51%) concentrations, measured by hippocampal microdialysis in vivo. Taken together, a picture emerges in which a reduction in the astrocytic formation of KYNA increases glutamatergic tone in the hippocampus and enhances cognitive abilities and synaptic plasticity. Our studies raise the prospect that interventions aimed specifically at reducing KYNA formation in the brain may constitute a promising molecular strategy for cognitive improvement in health and disease." @default.
• W2000183088 created "2016-06-24" @default.
• W2000183088 creator A5032693937 @default.
• W2000183088 creator A5047555416 @default.
• W2000183088 creator A5049171963 @default.
• W2000183088 creator A5064310112 @default.
• W2000183088 creator A5065965351 @default.
• W2000183088 creator A5069117192 @default.
• W2000183088 creator A5082985493 @default.
• W2000183088 date "2010-03-24" @default.
• W2000183088 modified "2023-10-17" @default.
• W2000183088 title "Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior" @default.
• W2000183088 cites W192631905 @default.
• W2000183088 cites W1971327448 @default.
• W2000183088 cites W1976175452 @default.
• W2000183088 cites W1981361777 @default.
• W2000183088 cites W1985615482 @default.
• W2000183088 cites W1989059619 @default.
• W2000183088 cites W1990672257 @default.
• W2000183088 cites W1993419219 @default.
• W2000183088 cites W2004578815 @default.
• W2000183088 cites W2008964179 @default.
• W2000183088 cites W2009782005 @default.
• W2000183088 cites W2012684633 @default.
• W2000183088 cites W2013712110 @default.
• W2000183088 cites W2014527159 @default.
• W2000183088 cites W2015380548 @default.
• W2000183088 cites W2016971764 @default.
• W2000183088 cites W2017661386 @default.
• W2000183088 cites W2018885303 @default.
• W2000183088 cites W2020949930 @default.
• W2000183088 cites W2026565164 @default.
• W2000183088 cites W2028370746 @default.
• W2000183088 cites W2034352381 @default.
• W2000183088 cites W2035531189 @default.
• W2000183088 cites W2036580198 @default.
• W2000183088 cites W2046411639 @default.
• W2000183088 cites W2055084868 @default.
• W2000183088 cites W2057095578 @default.
• W2000183088 cites W2059495695 @default.
• W2000183088 cites W2066656691 @default.
• W2000183088 cites W2067494870 @default.
• W2000183088 cites W2071113852 @default.
• W2000183088 cites W2072058525 @default.
• W2000183088 cites W2079199493 @default.
• W2000183088 cites W2083373623 @default.
• W2000183088 cites W2083942245 @default.
• W2000183088 cites W2095187162 @default.
• W2000183088 cites W2095294770 @default.
• W2000183088 cites W2100040827 @default.
• W2000183088 cites W2104838343 @default.
• W2000183088 cites W2106459619 @default.
• W2000183088 cites W2111909949 @default.
• W2000183088 cites W2113481800 @default.
• W2000183088 cites W2115460562 @default.
• W2000183088 cites W2120276500 @default.
• W2000183088 cites W2122321808 @default.
• W2000183088 cites W2128931606 @default.
• W2000183088 cites W2129761500 @default.
• W2000183088 cites W2131932927 @default.
• W2000183088 cites W2136729540 @default.
• W2000183088 cites W2147166014 @default.
• W2000183088 cites W2152480877 @default.
• W2000183088 cites W2154565921 @default.
• W2000183088 cites W2161074753 @default.
• W2000183088 cites W2161982488 @default.
• W2000183088 cites W2162287169 @default.
• W2000183088 cites W2166338743 @default.
• W2000183088 cites W2320877828 @default.
• W2000183088 doi "https://doi.org/10.1038/npp.2010.39" @default.
• W2000183088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3055476" @default.
• W2000183088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20336058" @default.
• W2000183088 hasPublicationYear "2010" @default.
• W2000183088 type Work @default.
• W2000183088 sameAs 2000183088 @default.
• W2000183088 citedByCount "183" @default.
• W2000183088 countsByYear W20001830882012 @default.
• W2000183088 countsByYear W20001830882013 @default.
• W2000183088 countsByYear W20001830882014 @default.
• W2000183088 countsByYear W20001830882015 @default.
• W2000183088 countsByYear W20001830882016 @default.
• W2000183088 countsByYear W20001830882017 @default.
• W2000183088 countsByYear W20001830882018 @default.
• W2000183088 countsByYear W20001830882019 @default.
• W2000183088 countsByYear W20001830882020 @default.
• W2000183088 countsByYear W20001830882021 @default.
• W2000183088 countsByYear W20001830882022 @default.
• W2000183088 countsByYear W20001830882023 @default.
• W2000183088 crossrefType "journal-article" @default.
• W2000183088 hasAuthorship W2000183088A5032693937 @default.
• W2000183088 hasAuthorship W2000183088A5047555416 @default.
• W2000183088 hasAuthorship W2000183088A5049171963 @default.
• W2000183088 hasAuthorship W2000183088A5064310112 @default.
• W2000183088 hasAuthorship W2000183088A5065965351 @default.
• W2000183088 hasAuthorship W2000183088A5069117192 @default.
• W2000183088 hasAuthorship W2000183088A5082985493 @default.
• W2000183088 hasBestOaLocation W20001830881 @default.
• W2000183088 hasConcept C148762608 @default.

• next