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- W2000200558 endingPage "69" @default.
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- W2000200558 abstract "Calcineurin signaling plays diverse roles in fungi in regulating stress responses, morphogenesis and pathogenesis. Although calcineurin signaling is conserved among fungi, recent studies indicate important divergences in calcineurin-dependent cellular functions among different human fungal pathogens. Fungal pathogens utilize the calcineurin pathway to effectively survive the host environment and cause life-threatening infections. The immunosuppressive calcineurin inhibitors (FK506 and cyclosporine A) are active against fungi, making targeting calcineurin a promising antifungal drug development strategy. Here we summarize current knowledge on calcineurin in yeasts and filamentous fungi, and review the importance of understanding fungal-specific attributes of calcineurin to decipher fungal pathogenesis and develop novel antifungal therapeutic approaches." @default.
- W2000200558 created "2016-06-24" @default.
- W2000200558 creator A5014148691 @default.
- W2000200558 creator A5015691337 @default.
- W2000200558 creator A5056810823 @default.
- W2000200558 date "2014-10-01" @default.
- W2000200558 modified "2023-10-08" @default.
- W2000200558 title "Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis" @default.
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