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- W2000200816 abstract "Significance Voltage-gated sodium (Na v ) channels are members of a large complex that plays a crucial role in rapid electrical signaling throughout the human body. As prominent members of this complex, β-subunits modify Na v channel function and cause debilitating disorders when mutated. Collectively, the functional and crystallographic results reported in this work uncover intricate interactions of these elements within the Na v -channel signaling complex and establish a key role for β-subunits in shaping Na v 1.2 pharmacology. An important concept emerging from our results is that β-subunits provide exciting opportunities for designing new therapeutic strategies to correct their abnormal behaviors." @default.
- W2000200816 created "2016-06-24" @default.
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- W2000200816 date "2013-12-02" @default.
- W2000200816 modified "2023-10-11" @default.
- W2000200816 title "Crystallographic insights into sodium-channel modulation by the β4 subunit" @default.
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- W2000200816 doi "https://doi.org/10.1073/pnas.1314557110" @default.
- W2000200816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3870679" @default.
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