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• W2000202909 abstract "To evaluate pregnancy safety of anti-TNF-α medications.Prospective, comparative, observational study done at the Israeli Teratology Information Service between 2002 and 2011.83 anti-TNF-α-exposed-pregnancies (97.6% in the first trimester, T1) were followed-up and compared with 86 disease-matched (DM) and 341 non-teratogenic-exposed (NTE) pregnancies. The anti-TNF-α group consisted of 35 infliximab-, 25 etanercept-, and 23 adalimumab-exposed pregnancies. The rate of major congenital anomalies did not significantly differ between the three groups [3/65 (4.6%) (anti-TNF-α, T1), 5/79 (6.3%) (DM), 8/336 (2.4%) (NTE)], even after excluding genetic or cytogenetic anomalies [3/65 (4.6%) (anti-TNF-α, T1), 4/79 (5.1%) (DM), 6/336 (1.8%) (NTE)]. There were no cases of VATER/VACTERL association.The present study suggests that anti-TNF-α treatment does not pose a major teratogenic risk in humans. This conclusion is based on relatively small numbers of exposed pregnancies and should be interpreted with caution. Larger studies are needed to establish anti-TNF-α pregnancy safety." @default.
• W2000202909 created "2016-06-24" @default.
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• W2000202909 date "2014-01-01" @default.
• W2000202909 modified "2023-10-13" @default.
• W2000202909 title "Pregnancy outcome following gestational exposure to TNF-alpha-inhibitors: A prospective, comparative, observational study" @default.
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• W2000202909 doi "https://doi.org/10.1016/j.reprotox.2013.11.004" @default.
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