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- W2000202941 endingPage "455" @default.
- W2000202941 startingPage "439" @default.
- W2000202941 abstract "Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10–20% of patients with DTC. Standard therapy (surgery, RAI, TSH suppression with levothyroxine) is ineffective for many of these patients, as is standard chemotherapy. Our understanding of the molecular mechanisms leading to DTC and the transformation to advanced DTC has rapidly evolved over the past 15–20 years. Newer targeted therapy, specifically inhibitors of intracellular kinase signaling pathways, and cooperative multicenter clinical trials have dramatically changed the therapeutic landscape for patients with advanced DTC. In this review focusing on morbidities, molecules, and medicinals, we present a patient with advanced DTC, explore the genetics and molecular biology of advanced DTC, and review evolving therapies for these patients including multikinase inhibitors, selective kinase inhibitors, and combination therapies." @default.
- W2000202941 created "2016-06-24" @default.
- W2000202941 creator A5030374801 @default.
- W2000202941 creator A5073085667 @default.
- W2000202941 date "2013-06-01" @default.
- W2000202941 modified "2023-10-18" @default.
- W2000202941 title "Evolving Approaches to Patients with Advanced Differentiated Thyroid Cancer" @default.
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