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- W2000203225 abstract "Abstract MicroRNAs are a class of small endogenous non‐coding RNAs that function as post‐transcriptional regulators. In our previous study, we found that miR‐181b was significantly downregulated in human gastric adenocarcinoma tissue samples compared to the adjacent normal gastric tissues. In this study, we confirm the down‐regulation of miR‐181b in human gastric cancer cell lines versus the gastric epithelial cells. Overexpression of miR‐181b suppressed the proliferation and colony formation rate of gastric cancer cells. miR‐181b downregulated the expression of cAMP responsive element binding protein 1 (CREB1) by binding its 3′ untranslated region. Overexpression of CREB1 counteracted the suppression of growth in gastric cancer cells caused by ectopic expression of miR‐181b. These results indicate that miR‐181b may function as a tumor suppressor in gastric adenocarcinoma cells through negative regulation of CREB1. © 2012 IUBMB IUBMB Life, 64(7): 628–635, 2012" @default.
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- W2000203225 date "2012-04-27" @default.
- W2000203225 modified "2023-10-16" @default.
- W2000203225 title "MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas" @default.
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- W2000203225 doi "https://doi.org/10.1002/iub.1030" @default.
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