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• W2000204932 abstract "Dioscorea bulbifera is a potent medicinal plant used in both Indian and Chinese traditional medicine owing to its rich phytochemical diversity. Herein, we report the rapid synthesis of novel<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:msub><mml:mrow><mml:mtext>Au</mml:mtext></mml:mrow><mml:mrow><mml:mtext>core</mml:mtext></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mtext>Ag</mml:mtext></mml:mrow><mml:mrow><mml:mtext>shell</mml:mtext></mml:mrow></mml:msub></mml:math>nanoparticles by D. bulbifera tuber extract (DBTE).<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:msub><mml:mrow><mml:mtext>Au</mml:mtext></mml:mrow><mml:mrow><mml:mtext>core</mml:mtext></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mtext>Ag</mml:mtext></mml:mrow><mml:mrow><mml:mtext>shell</mml:mtext></mml:mrow></mml:msub></mml:math>NPs synthesis was completed within 5 h showing a prominent peak at 540 nm. HRTEM analysis revealed 9 nm inner core of elemental gold covered by a silver shell giving a total particle diameter upto 15 nm.<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:msub><mml:mrow><mml:mtext>Au</mml:mtext></mml:mrow><mml:mrow><mml:mtext>core</mml:mtext></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mtext>Ag</mml:mtext></mml:mrow><mml:mrow><mml:mtext>shell</mml:mtext></mml:mrow></mml:msub></mml:math>NPs were comprised of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn>57.34</mml:mn><mml:mo>±</mml:mo><mml:mn>1.01</mml:mn></mml:math>% gold and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mn>42.66</mml:mn><mml:mo>±</mml:mo><mml:mn>0.97</mml:mn></mml:math>% silver of the total mass.<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:msub><mml:mrow><mml:mtext>Au</mml:mtext></mml:mrow><mml:mrow><mml:mtext>core</mml:mtext></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mtext>Ag</mml:mtext></mml:mrow><mml:mrow><mml:mtext>shell</mml:mtext></mml:mrow></mml:msub></mml:math>NPs showed highest biofilm inhibition upto<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mn>83.68</mml:mn><mml:mo>±</mml:mo><mml:mn>0.09</mml:mn></mml:math>% against A. baumannii . Biofilms of P. aeruginosa , E. coli , and S. aureus were inhibited up to<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mn>18.93</mml:mn><mml:mo>±</mml:mo><mml:mn>1.94</mml:mn></mml:math>%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mn>22.33</mml:mn><mml:mo>±</mml:mo><mml:mn>0.56</mml:mn></mml:math>%, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mn>30.70</mml:mn><mml:mo>±</mml:mo><mml:mn>1.33</mml:mn></mml:math>%, respectively. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) confirmed unregulated cellular efflux through pore formation leading to cell death. Potent antileishmanial activity of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:msub><mml:mrow><mml:mtext>Au</mml:mtext></mml:mrow><mml:mrow><mml:mtext>core</mml:mtext></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mtext>Ag</mml:mtext></mml:mrow><mml:mrow><mml:mtext>shell</mml:mtext></mml:mrow></mml:msub></mml:math>NPs (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mtext>MIC</mml:mtext><mml:mo>=</mml:mo><mml:mn>32</mml:mn></mml:math> µ g/mL) was confirmed by MTT assay. Further SEM micrographs showed pronounced deformity in the spindle shaped cellular morphology changing to spherical. This is the first report of synthesis, characterization, antibiofilm, and antileishmanial activity of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:msub><mml:mrow><mml:mtext>Au</mml:mtext></mml:mrow><mml:mrow><mml:mtext>core</mml:mtext></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mtext>Ag</mml:mtext></mml:mrow><mml:mrow><mml:mtext>shell</mml:mtext></mml:mrow></mml:msub></mml:math>NPs synthesized by D. bulbifera ." @default.
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• W2000204932 date "2015-01-01" @default.
• W2000204932 modified "2023-09-30" @default.
• W2000204932 title "<i>Dioscorea bulbifera</i>Mediated Synthesis of Novel Au_coreAg_shellNanoparticles with Potent Antibiofilm and Antileishmanial Activity" @default.
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• W2000204932 doi "https://doi.org/10.1155/2015/562938" @default.
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