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- W2000205486 abstract "Two additional urinary metabolites of the chemical oncogen 3-hydroxyxanthine are now identified as 8-chloroxanthine and 8-methylmercaptoxanthine. Such products are thought to be derived from a reactive intermediate which can be tentatively considered to be a proximate oncogen. Since each of these 8-substituted xanthines has also been obtained in vitro by reactions of 3-acetoxyxanthine with chloride ion or methionine, their production in vivo can be explained as resulting through the metabolic formation of an activated ester with a reactivity similar to that of the chemical model." @default.
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- W2000205486 date "1970-03-20" @default.
- W2000205486 modified "2023-09-23" @default.
- W2000205486 title "Oncogenic Purine Derivatives: Evidence for a Possible Proximate Oncogen" @default.
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- W2000205486 doi "https://doi.org/10.1126/science.167.3925.1622" @default.
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