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- W2000205853 abstract "Abstract Analogues of NAD and NADP were prepared from cotinine, the major metabolite of nicotine, through the NADase-catalyzed exchange reaction These cotinine analogues and the corresponding nicotine analogues were hydrolyzed by snake venom nucleotide pyrophosphatase to produce the mononucleotides The ribosides of nicotine and cotinine were prepared from the mononucleotides by hydrolysis with snake venom 5'-nucleotidase The mononucleotide was the major product formed when (nicotine)AD or (cotinine)AD was incubated with a rabbit liver microsomal fraction. However, the ribosides were not detected when the mononueleotides were incubated with rabbit liver extract. If the nucleotide analogues are formed in vivo , the possibility exists that nicotine and cotinine mononucleotides could accumulate inside the cell." @default.
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- W2000205853 date "1977-10-01" @default.
- W2000205853 modified "2023-10-17" @default.
- W2000205853 title "Nicotinamide nucleotide analogues of nicotine and cotinine—enzymic studies" @default.
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- W2000205853 doi "https://doi.org/10.1016/0006-2952(77)90156-3" @default.
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