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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000208521> ?p ?o ?g. }

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• W2000208521 abstract "In this study, the capacity for t-PA to affect T cell-brain microvascular endothelial cell adhesion by acting as a cytokine was investigated. Following the treatment of a brain-derived endothelial cell line, bEnd.3, with various concentrations of t-PA, adhesion and transwell migration assays were performed. In the presence of t-PA, enhanced adhesion of T cells to bEnd.3 cells was observed. Using western blot analysis, an increase in ICAM-1 expression was detected for both t-PA-treated bEnd.3 cells and bEnd.3 cells treated with a non-enzymatic form of t-PA. In contrast, when LRP1 was blocked using a specific antibody, upregulation of ICAM-1 was inhibited and cAMP–PKA signaling was affected. Furthermore, using an EAE mouse model, administration of t-PA was associated with an increase in ICAM-1 expression by brain endothelial cells. Taken together, these findings suggest that t-PA can induce ICAM-1 expression in brain microvascular endothelial cells, and this may promote the development of EAE." @default.
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• W2000208521 date "2010-11-01" @default.
• W2000208521 modified "2023-10-14" @default.
• W2000208521 title "Nanoparticles against Alzheimer's disease: PEG–PACA nanoparticles are able to link the aβ-peptide and influence its aggregation kinetic" @default.
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• W2000208521 doi "https://doi.org/10.1016/j.jconrel.2010.07.084" @default.
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