FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000208636> ?p ?o ?g. }

• W2000208636 endingPage "6" @default.
• W2000208636 startingPage "1" @default.
• W2000208636 abstract "Nephrotoxic aristolochic acids (AAs) form covalently bonded DNA adducts upon metabolic activation. In this work, a non-invasive approach to detect AAs exposure by quantifying urinary excreted DNA-AA adducts is presented. The developed method entails solid-phase extraction (SPE) enrichment of the urine-excreted DNA-AAs adducts, addition of internal standard, and quantification by liquid chromatography coupled tandem mass spectrometric (LC–MS/MS) analysis. Quantitative analysis revealed 7-(deoxyadenosine-N6-yl)-aristolactam II and 7-(deoxyguanosine-N2-yl)-aristolactam I that were previously detected as major DNA-AA adducts in different organs of AA-dosed rats, were detected as the major urine excreted adducts. Lower levels of 7-(deoxyadenosine-N6-yl)-aristolactam I and 7-(deoxyguanosine-N2-yl)-aristolactam II were also detected in the collected urine samples. The identities of the detected urinary DNA-AA adducts were confirmed by comparing chromatographic retention time with synthetic standards, by high-accuracy MS, and MS/MS analyses. LC–MS/MS analysis of the urine samples collected from the AAs-dosed rats demonstrated a time-dependent decrease in the urinary adduct levels, indicating the urinary DNA-AA adduct levels were reflective of the tissue adduct levels. It is expected that the developed approach of detecting urinary DNA-AA adducts will facilitate further carcinogenesis investigations of AAs." @default.
• W2000208636 created "2016-06-24" @default.
• W2000208636 creator A5019220796 @default.
• W2000208636 creator A5024139889 @default.
• W2000208636 date "2014-08-01" @default.
• W2000208636 modified "2023-10-01" @default.
• W2000208636 title "Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms" @default.
• W2000208636 cites W1964466677 @default.
• W2000208636 cites W1981835502 @default.
• W2000208636 cites W2001364126 @default.
• W2000208636 cites W2022891680 @default.
• W2000208636 cites W2023306589 @default.
• W2000208636 cites W2027621465 @default.
• W2000208636 cites W2031136406 @default.
• W2000208636 cites W2045744177 @default.
• W2000208636 cites W2046672098 @default.
• W2000208636 cites W2050958285 @default.
• W2000208636 cites W2061376602 @default.
• W2000208636 cites W2065434654 @default.
• W2000208636 cites W2073866669 @default.
• W2000208636 cites W2075053628 @default.
• W2000208636 cites W2076766299 @default.
• W2000208636 cites W2082527625 @default.
• W2000208636 cites W2085212528 @default.
• W2000208636 cites W2087692510 @default.
• W2000208636 cites W2090093965 @default.
• W2000208636 cites W2105675157 @default.
• W2000208636 cites W2115780437 @default.
• W2000208636 cites W2120221084 @default.
• W2000208636 cites W2121184922 @default.
• W2000208636 cites W2124581521 @default.
• W2000208636 cites W2162463986 @default.
• W2000208636 cites W2167068573 @default.
• W2000208636 cites W2172021748 @default.
• W2000208636 doi "https://doi.org/10.1016/j.mrfmmm.2014.05.004" @default.
• W2000208636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25847264" @default.
• W2000208636 hasPublicationYear "2014" @default.
• W2000208636 type Work @default.
• W2000208636 sameAs 2000208636 @default.
• W2000208636 citedByCount "21" @default.
• W2000208636 countsByYear W20002086362015 @default.
• W2000208636 countsByYear W20002086362017 @default.
• W2000208636 countsByYear W20002086362018 @default.
• W2000208636 countsByYear W20002086362020 @default.
• W2000208636 countsByYear W20002086362021 @default.
• W2000208636 countsByYear W20002086362022 @default.
• W2000208636 countsByYear W20002086362023 @default.
• W2000208636 crossrefType "journal-article" @default.
• W2000208636 hasAuthorship W2000208636A5019220796 @default.
• W2000208636 hasAuthorship W2000208636A5024139889 @default.
• W2000208636 hasConcept C108204754 @default.
• W2000208636 hasConcept C162356407 @default.
• W2000208636 hasConcept C178790620 @default.
• W2000208636 hasConcept C185592680 @default.
• W2000208636 hasConcept C2780026642 @default.
• W2000208636 hasConcept C2780441211 @default.
• W2000208636 hasConcept C2780636463 @default.
• W2000208636 hasConcept C2780813843 @default.
• W2000208636 hasConcept C2781247443 @default.
• W2000208636 hasConcept C31827203 @default.
• W2000208636 hasConcept C43617362 @default.
• W2000208636 hasConcept C54355233 @default.
• W2000208636 hasConcept C552990157 @default.
• W2000208636 hasConcept C55493867 @default.
• W2000208636 hasConcept C86803240 @default.
• W2000208636 hasConceptScore W2000208636C108204754 @default.
• W2000208636 hasConceptScore W2000208636C162356407 @default.
• W2000208636 hasConceptScore W2000208636C178790620 @default.
• W2000208636 hasConceptScore W2000208636C185592680 @default.
• W2000208636 hasConceptScore W2000208636C2780026642 @default.
• W2000208636 hasConceptScore W2000208636C2780441211 @default.
• W2000208636 hasConceptScore W2000208636C2780636463 @default.
• W2000208636 hasConceptScore W2000208636C2780813843 @default.
• W2000208636 hasConceptScore W2000208636C2781247443 @default.
• W2000208636 hasConceptScore W2000208636C31827203 @default.
• W2000208636 hasConceptScore W2000208636C43617362 @default.
• W2000208636 hasConceptScore W2000208636C54355233 @default.
• W2000208636 hasConceptScore W2000208636C552990157 @default.
• W2000208636 hasConceptScore W2000208636C55493867 @default.
• W2000208636 hasConceptScore W2000208636C86803240 @default.
• W2000208636 hasLocation W20002086361 @default.
• W2000208636 hasLocation W20002086362 @default.
• W2000208636 hasOpenAccess W2000208636 @default.
• W2000208636 hasPrimaryLocation W20002086361 @default.
• W2000208636 hasRelatedWork W1771225617 @default.
• W2000208636 hasRelatedWork W1977915969 @default.
• W2000208636 hasRelatedWork W2000208636 @default.
• W2000208636 hasRelatedWork W2049862580 @default.
• W2000208636 hasRelatedWork W2052214893 @default.
• W2000208636 hasRelatedWork W2079902812 @default.
• W2000208636 hasRelatedWork W2129485292 @default.
• W2000208636 hasRelatedWork W2163439067 @default.
• W2000208636 hasRelatedWork W2425651633 @default.
• W2000208636 hasRelatedWork W4237081677 @default.
• W2000208636 hasVolume "766-767" @default.
• W2000208636 isParatext "false" @default.
• W2000208636 isRetracted "false" @default.
• W2000208636 magId "2000208636" @default.

• next