FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000209280> ?p ?o ?g. }

• W2000209280 endingPage "450" @default.
• W2000209280 startingPage "441" @default.
• W2000209280 abstract "Previous studies showed that prior administration of kappa-opioid agonists decreased the development of sensitization to some of the behavioral effects of cocaine. The present study sought to determine whether the development of sensitization to cocaine's reinforcing effects was also sensitive to antagonism by kappa-opioid agonists. During a pretreatment phase, the kappa-opioid agonist, U69593 (0.0 or 0.32 mg/kg) was administered prior to (1) 2 daily injections of cocaine (0.0 or 20.0 mg/kg), or (2) cocaine or saline administered via a yoking procedure. Cocaine pretreatment decreased the latency to acquisition of cocaine self-administration. However, prior administration of U69593 during the pretreatment phase failed to attenuate the development of this sensitized response to cocaine's reinforcing effect. In other groups, the effect of acute U69593 pretreatment on the maintenance of cocaine self-administration was examined during a 10 hr session. During training and testing, a stimulus was associated with each self-administered cocaine infusion for one group whereas responding of another group was reinforced by a cocaine infusion alone. On the test day, pretreatment with U69593 (0.32 mg/kg) decreased responding during each hour of the 10 hr session for the group that was reinforced with cocaine plus the cocaine-associated stimulus. U69593 failed to produce a long-lasting disruption of cocaine self-administration for rats that were trained and tested without the cocaine-associated stimulus. These data suggest that the acquisition and maintenance of cocaine self-administration are differentially sensitive to manipulations of kappa-opioid systems. Further, the disruption of cocaine self-administration by U69593 may be due to interactions with mechanisms that underlie facilitative effects of stimuli that have been associated with self-administered cocaine infusions." @default.
• W2000209280 created "2016-06-24" @default.
• W2000209280 creator A5006357330 @default.
• W2000209280 date "2001-04-01" @default.
• W2000209280 modified "2023-10-11" @default.
• W2000209280 title "Effects of the Kappa-opioid Receptor Agonist, U69593, on the Development of Sensitization and on the Maintenance of Cocaine Self-administration" @default.
• W2000209280 cites W1939305793 @default.
• W2000209280 cites W1943544645 @default.
• W2000209280 cites W1975992711 @default.
• W2000209280 cites W1982114367 @default.
• W2000209280 cites W1987070865 @default.
• W2000209280 cites W1996704538 @default.
• W2000209280 cites W1997474889 @default.
• W2000209280 cites W1999971120 @default.
• W2000209280 cites W2001837815 @default.
• W2000209280 cites W2007577290 @default.
• W2000209280 cites W2012129826 @default.
• W2000209280 cites W2013690942 @default.
• W2000209280 cites W2013979889 @default.
• W2000209280 cites W2019174511 @default.
• W2000209280 cites W2021511123 @default.
• W2000209280 cites W2029561008 @default.
• W2000209280 cites W2030078771 @default.
• W2000209280 cites W2031101928 @default.
• W2000209280 cites W2033123455 @default.
• W2000209280 cites W2035070639 @default.
• W2000209280 cites W2035819219 @default.
• W2000209280 cites W2038733942 @default.
• W2000209280 cites W2041080698 @default.
• W2000209280 cites W2048921553 @default.
• W2000209280 cites W2052630265 @default.
• W2000209280 cites W2059512977 @default.
• W2000209280 cites W2060941708 @default.
• W2000209280 cites W2061344417 @default.
• W2000209280 cites W2061418383 @default.
• W2000209280 cites W2072886182 @default.
• W2000209280 cites W2075869961 @default.
• W2000209280 cites W2081041064 @default.
• W2000209280 cites W2087685262 @default.
• W2000209280 cites W2090793677 @default.
• W2000209280 cites W2093263661 @default.
• W2000209280 cites W2106862702 @default.
• W2000209280 cites W2108098398 @default.
• W2000209280 cites W2114740171 @default.
• W2000209280 cites W2129159257 @default.
• W2000209280 cites W2133672910 @default.
• W2000209280 cites W2224286518 @default.
• W2000209280 cites W2262509036 @default.
• W2000209280 cites W2268522412 @default.
• W2000209280 cites W2275219801 @default.
• W2000209280 cites W2275331720 @default.
• W2000209280 cites W1523498546 @default.
• W2000209280 doi "https://doi.org/10.1016/s0893-133x(00)00190-1" @default.
• W2000209280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11182539" @default.
• W2000209280 hasPublicationYear "2001" @default.
• W2000209280 type Work @default.
• W2000209280 sameAs 2000209280 @default.
• W2000209280 citedByCount "32" @default.
• W2000209280 countsByYear W20002092802012 @default.
• W2000209280 countsByYear W20002092802013 @default.
• W2000209280 countsByYear W20002092802014 @default.
• W2000209280 countsByYear W20002092802015 @default.
• W2000209280 countsByYear W20002092802017 @default.
• W2000209280 countsByYear W20002092802019 @default.
• W2000209280 countsByYear W20002092802020 @default.
• W2000209280 countsByYear W20002092802021 @default.
• W2000209280 countsByYear W20002092802023 @default.
• W2000209280 crossrefType "journal-article" @default.
• W2000209280 hasAuthorship W2000209280A5006357330 @default.
• W2000209280 hasBestOaLocation W20002092801 @default.
• W2000209280 hasConcept C126322002 @default.
• W2000209280 hasConcept C15744967 @default.
• W2000209280 hasConcept C169760540 @default.
• W2000209280 hasConcept C170493617 @default.
• W2000209280 hasConcept C184389661 @default.
• W2000209280 hasConcept C2776217527 @default.
• W2000209280 hasConcept C2778555786 @default.
• W2000209280 hasConcept C2778938600 @default.
• W2000209280 hasConcept C2779886867 @default.
• W2000209280 hasConcept C2781063702 @default.
• W2000209280 hasConcept C71924100 @default.
• W2000209280 hasConcept C98274493 @default.
• W2000209280 hasConceptScore W2000209280C126322002 @default.
• W2000209280 hasConceptScore W2000209280C15744967 @default.
• W2000209280 hasConceptScore W2000209280C169760540 @default.
• W2000209280 hasConceptScore W2000209280C170493617 @default.
• W2000209280 hasConceptScore W2000209280C184389661 @default.
• W2000209280 hasConceptScore W2000209280C2776217527 @default.
• W2000209280 hasConceptScore W2000209280C2778555786 @default.
• W2000209280 hasConceptScore W2000209280C2778938600 @default.
• W2000209280 hasConceptScore W2000209280C2779886867 @default.
• W2000209280 hasConceptScore W2000209280C2781063702 @default.
• W2000209280 hasConceptScore W2000209280C71924100 @default.
• W2000209280 hasConceptScore W2000209280C98274493 @default.
• W2000209280 hasIssue "4" @default.
• W2000209280 hasLocation W20002092801 @default.
• W2000209280 hasLocation W20002092802 @default.
• W2000209280 hasOpenAccess W2000209280 @default.

• next