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• W2000209912 abstract "The present study was undertaken to identify the mechanisms underlying the effect of retinoic acid (RA) on the luteinizing hormone receptor (LH-R) in rat granulosa cells. Treatment with FSH produced a substantial increase in LH-R mRNA level, as was expected, while concurrent treatment with increasing concentrations of RA brought about dose-dependent decreases in FSH-induced LH-R mRNA. RA, either alone or in combination with FSH, did not affect intracellular cAMP levels, while it inhibited the effect of 8-Br-cAMP on LH-R mRNA production. Whether the effect of RA and FSH on LH-R mRNA levels was the result of decreased transcription and/or altered mRNA stability was also investigated. The rate of LH receptor mRNA gene transcription, assessed by nuclear run-on transcription assay, was inhibited by the addition of RA. The effect of RA on LH-R mRNA stability was determined by measuring the decay of LH receptor mRNA under conditions known to inhibit transcription. The decay curves for the 5.4-kb LH-R mRNA transcript showed a significant decrease after the addition of RA. It may be possible that RA not only inhibits FSH-induced transcription but also stimulates the production of destabilizing factors for the LH-R mRNA. These findings assist in understanding the molecular mechanism underlying the effect of RA on reproductive function in rat granulosa cells." @default.
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• W2000209912 date "2000-01-01" @default.
• W2000209912 modified "2023-10-13" @default.
• W2000209912 title "Retinoic Acid (RA) Represses Follicle Stimulating Hormone (FSH)-Induced Luteinizing Hormone (LH) Receptor in Rat Granulosa Cells" @default.
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• W2000209912 doi "https://doi.org/10.1006/abbi.1999.1528" @default.
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