FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000210208> ?p ?o ?g. }

• W2000210208 endingPage "338" @default.
• W2000210208 startingPage "332" @default.
• W2000210208 abstract "The ribosomal acidic P0 protein, an essential component of the eukaryotic ribosomal stalk, was found to interact with the helix-loop-helix protein human Grap2 and cyclin D interacting protein (GCIP)/D-type cyclin-interacting protein 1/human homolog of MAID protein. Using in vivo and in vitro binding assays, we show that P0 can interact with the N and C termini of GCIP via its N-terminal 39-114 amino-acid residues. Although the P0-GCIP complex was detected mainly in cytoplasmic fraction, polysome profile analysis indicated that the P0-GCIP complex did not coelute with either polysomes or 60S ribosomes, suggesting that GCIP associates with the free form of P0 in the cytoplasm. Transfection of GCIP into MCF-7 cells resulted in decreased levels of pRb phosphorylation. Cotransfection of P0 with GCIP, however, resulted in GCIP-mediated reduction of pRb phosphorylation level which was repressed by P0. Furthermore, overexpression of P0 in breast cancer and hepatocellular cancer cell lines promoted cell growth and colony formation compared to control transfectants. Overexpression of P0 also increased cyclin D1 expression and phosphorylation of pRb at Ser780. Interestingly, P0 mRNA was overexpressed in 12 of 20 pairs of breast cancer/ normal breast specimens (60%). Together, these data indicate that P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression." @default.
• W2000210208 created "2016-06-24" @default.
• W2000210208 creator A5007830535 @default.
• W2000210208 creator A5016597289 @default.
• W2000210208 creator A5023345275 @default.
• W2000210208 creator A5053617864 @default.
• W2000210208 creator A5066050891 @default.
• W2000210208 creator A5078440715 @default.
• W2000210208 date "2007-07-09" @default.
• W2000210208 modified "2023-09-27" @default.
• W2000210208 title "Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells" @default.
• W2000210208 cites W1568474642 @default.
• W2000210208 cites W1965292680 @default.
• W2000210208 cites W1979104068 @default.
• W2000210208 cites W1983220403 @default.
• W2000210208 cites W1993904127 @default.
• W2000210208 cites W1994220194 @default.
• W2000210208 cites W1995989104 @default.
• W2000210208 cites W2013474812 @default.
• W2000210208 cites W2028572911 @default.
• W2000210208 cites W2083697616 @default.
• W2000210208 cites W2090027930 @default.
• W2000210208 cites W2096817012 @default.
• W2000210208 cites W2102791027 @default.
• W2000210208 cites W2102942479 @default.
• W2000210208 cites W2138968091 @default.
• W2000210208 cites W2144653187 @default.
• W2000210208 cites W2148856358 @default.
• W2000210208 cites W31572314 @default.
• W2000210208 doi "https://doi.org/10.1038/sj.onc.1210651" @default.
• W2000210208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17621266" @default.
• W2000210208 hasPublicationYear "2007" @default.
• W2000210208 type Work @default.
• W2000210208 sameAs 2000210208 @default.
• W2000210208 citedByCount "46" @default.
• W2000210208 countsByYear W20002102082012 @default.
• W2000210208 countsByYear W20002102082013 @default.
• W2000210208 countsByYear W20002102082014 @default.
• W2000210208 countsByYear W20002102082015 @default.
• W2000210208 countsByYear W20002102082016 @default.
• W2000210208 countsByYear W20002102082018 @default.
• W2000210208 countsByYear W20002102082019 @default.
• W2000210208 countsByYear W20002102082020 @default.
• W2000210208 countsByYear W20002102082021 @default.
• W2000210208 countsByYear W20002102082022 @default.
• W2000210208 countsByYear W20002102082023 @default.
• W2000210208 crossrefType "journal-article" @default.
• W2000210208 hasAuthorship W2000210208A5007830535 @default.
• W2000210208 hasAuthorship W2000210208A5016597289 @default.
• W2000210208 hasAuthorship W2000210208A5023345275 @default.
• W2000210208 hasAuthorship W2000210208A5053617864 @default.
• W2000210208 hasAuthorship W2000210208A5066050891 @default.
• W2000210208 hasAuthorship W2000210208A5078440715 @default.
• W2000210208 hasBestOaLocation W20002102081 @default.
• W2000210208 hasConcept C104317684 @default.
• W2000210208 hasConcept C11960822 @default.
• W2000210208 hasConcept C1491633281 @default.
• W2000210208 hasConcept C153911025 @default.
• W2000210208 hasConcept C199835354 @default.
• W2000210208 hasConcept C2776062698 @default.
• W2000210208 hasConcept C2777061661 @default.
• W2000210208 hasConcept C2780926556 @default.
• W2000210208 hasConcept C29537977 @default.
• W2000210208 hasConcept C502942594 @default.
• W2000210208 hasConcept C54009773 @default.
• W2000210208 hasConcept C54355233 @default.
• W2000210208 hasConcept C55493867 @default.
• W2000210208 hasConcept C555283112 @default.
• W2000210208 hasConcept C62112901 @default.
• W2000210208 hasConcept C65666806 @default.
• W2000210208 hasConcept C67705224 @default.
• W2000210208 hasConcept C81885089 @default.
• W2000210208 hasConcept C86803240 @default.
• W2000210208 hasConcept C87325107 @default.
• W2000210208 hasConcept C88478588 @default.
• W2000210208 hasConcept C95444343 @default.
• W2000210208 hasConcept C97029542 @default.
• W2000210208 hasConceptScore W2000210208C104317684 @default.
• W2000210208 hasConceptScore W2000210208C11960822 @default.
• W2000210208 hasConceptScore W2000210208C1491633281 @default.
• W2000210208 hasConceptScore W2000210208C153911025 @default.
• W2000210208 hasConceptScore W2000210208C199835354 @default.
• W2000210208 hasConceptScore W2000210208C2776062698 @default.
• W2000210208 hasConceptScore W2000210208C2777061661 @default.
• W2000210208 hasConceptScore W2000210208C2780926556 @default.
• W2000210208 hasConceptScore W2000210208C29537977 @default.
• W2000210208 hasConceptScore W2000210208C502942594 @default.
• W2000210208 hasConceptScore W2000210208C54009773 @default.
• W2000210208 hasConceptScore W2000210208C54355233 @default.
• W2000210208 hasConceptScore W2000210208C55493867 @default.
• W2000210208 hasConceptScore W2000210208C555283112 @default.
• W2000210208 hasConceptScore W2000210208C62112901 @default.
• W2000210208 hasConceptScore W2000210208C65666806 @default.
• W2000210208 hasConceptScore W2000210208C67705224 @default.
• W2000210208 hasConceptScore W2000210208C81885089 @default.
• W2000210208 hasConceptScore W2000210208C86803240 @default.
• W2000210208 hasConceptScore W2000210208C87325107 @default.
• W2000210208 hasConceptScore W2000210208C88478588 @default.

• next