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- W2000211105 abstract "Our understanding of the mechanisms by which intravenously transplanted hematopoietic stem/progenitor cells (HSPCs) home to and engraft the bone marrow (BM) remains incomplete, but participation of adhesion molecules has been documented. We here demonstrate that blockade of the α6-integrin enhanced BM homing of human and nonhuman primate BM-derived HSPCs by >60% in the xenogeneic transplant model and led to significantly improved engraftment. The effect was limited to BM-derived HSPCs, as granulocyte-colony-stimulating factor mobilized peripheral blood or cord blood HSPCs express little or no α6 integrin. By contrast, despite high α6 integrin expression, no effect of α6 blockade on murine BM-HSPCs homing/engraftment was observed." @default.
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- W2000211105 date "2009-07-01" @default.
- W2000211105 modified "2023-10-11" @default.
- W2000211105 title "Blockade of α6-Integrin Reveals Diversity in Homing Patterns Among Human, Baboon, and Murine Cells" @default.
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- W2000211105 doi "https://doi.org/10.1089/scd.2008.0269" @default.
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